Formation of classic pathway C5 convertase

Stable Identifier
R-HSA-173636
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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Formation of classic pathway C5 convertase
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C5 convertases are serine proteases that cleave C5 with high efficiency; the C3 convertases can cleave C5 but have a poor affinity for C5, with a Km of 6-9 microM. The high affinity C5 convertases are generated when the low affinity C3/C5 convertases such as C4b:C2a deposit C3b by cleaving native C3. These C3b-containing C3/C5 convertases have Km values of 0.005 microM, well below the normal concentration of C5 in blood (0.37 microM). They have very low Vmax rates, just one C5 cleaved per 1–4 min per enzyme (Rawal & Pangburn 1998).
Literature References
PubMed ID Title Journal Year
12878586 Formation of high affinity C5 convertase of the classical pathway of complement

Rawal, N, Pangburn, MK

J Biol Chem 2003
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Authored
de Bono, B  (2004-08-04)
Reviewed
Bradley, DT  (2013-05-28)
Created
de Bono, B  (2006-02-15)
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