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SRC-1 autophosphorylates
Stable Identifier
R-HSA-170991
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
,
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
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Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by NTRKs (Homo sapiens)
Signaling by NTRK1 (TRKA) (Homo sapiens)
Signalling to ERKs (Homo sapiens)
Signalling to RAS (Homo sapiens)
p38MAPK events (Homo sapiens)
SRC-1 autophosphorylates (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The active form of RAL, RAL-GTP, induces a conformational change in SRC-1, which autophosphorylates at tyrosine 419, thereby activating itself.
Participants
Input
ATP [cytosol]
SRC-1 [plasma membrane]
(Homo sapiens)
Output
ADP [cytosol]
p-Y419-SRC-1 [plasma membrane]
(Homo sapiens)
Participates
as an event of
p38MAPK events (Homo sapiens)
Catalyst Activity
protein tyrosine kinase activity of SRC-1 [plasma membrane]
Physical Entity
SRC-1 [plasma membrane]
(Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
This event is regulated
Positively by
Regulator
RAL-GTP [cytosol]
(Homo sapiens)
Inferred From
Activation of Src by Ral (Rattus norvegicus)
Authored
Nasi, S (2006-10-10)
Annibali, D (2006-10-10)
Reviewed
Greene, LA (2007-11-08)
Created
Jassal, B (2006-01-25)
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