Reactome | SRC-1 autophosphorylates

SRC-1 autophosphorylates

Stable Identifier

R-HSA-170991

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by NTRKs (Homo sapiens)
    - Signaling by NTRK1 (TRKA) (Homo sapiens)
      - Signalling to ERKs (Homo sapiens)
        
        Signalling to RAS (Homo sapiens)
        
        p38MAPK events (Homo sapiens)
        
        SRC-1 autophosphorylates (Homo sapiens)

General

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The active form of RAL, RAL-GTP, induces a conformational change in SRC-1, which autophosphorylates at tyrosine 419, thereby activating itself.

Participants

Input

Output

Participant Of

hasEvent

p38MAPK events

Catalyst Activity

Title

protein tyrosine kinase activity of SRC-1 [plasma membrane]

Physical Entity

SRC-1 [plasma membrane]

Activity

protein tyrosine kinase activity (0004713)

This event is regulated

Positively by

RAL-GTP [cytosol]

Inferred From

Activation of Src by Ral (Rattus norvegicus)

Authored

Nasi, S (2006-10-10)

Annibali, D (2006-10-10)

Reviewed

Greene, LA (2007-11-08)

Created

Jassal, B (2006-01-25)