An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3

Stable Identifier
R-HSA-170835
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The activated TGF-beta receptor complex is internalized by clathrin-mediated endocytosis into early endosomes. ZFYVE9 (SARA) resides in the membrane of early endosomes. Crystallographic studies suggest that dimeric SARA in the early endosome coordinates two R-SMAD molecules (SMAD2 and/or SMAD3) per one receptor complex.

Literature References
PubMed ID Title Journal Year
9865696 SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor

Tsukazaki, T, Chiang, TA, Davison, AF, Attisano, L, Wrana, JL

Cell 1998
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein binding activity of ZFYVE9-1 [early endosome membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created