An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3

Stable Identifier
R-HSA-170835
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytoplasmic side of plasma membrane
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An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3
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The activated TGF-beta receptor complex is internalized by clathrin-mediated endocytosis into early endosomes. ZFYVE9 (SARA) resides in the membrane of early endosomes. Crystallographic studies suggest that dimeric SARA in the early endosome coordinates two R-SMAD molecules (SMAD2 and/or SMAD3) per one receptor complex.

Literature References
PubMed ID Title Journal Year
9865696 SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor

Wrana, JL, Attisano, L, Chiang, TA, Davison, AF, Tsukazaki, T

Cell 1998
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Orthologous Events
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Authored
Jassal, B  (2006-02-02)
Huminiecki, L  (2006-02-02)
Moustakas, A  (2006-02-02)
Heldin, CH  (2006-02-02)
Reviewed
Huang, T  (2012-05-14)
Heldin, CH  (2006-04-18)
Created
Jassal, B  (2006-01-18)
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