An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3

Stable Identifier
R-HSA-170835
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytoplasmic side of plasma membrane
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An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3
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The activated TGF-beta receptor complex is internalized by clathrin-mediated endocytosis into early endosomes. ZFYVE9 (SARA) resides in the membrane of early endosomes. Crystallographic studies suggest that dimeric SARA in the early endosome coordinates two R-SMAD molecules (SMAD2 and/or SMAD3) per one receptor complex.

Literature References
PubMed ID Title Journal Year
9865696 SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor

Tsukazaki, T, Chiang, TA, Davison, AF, Attisano, L, Wrana, JL

Cell 1998
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
protein binding activity of ZFYVE9-1 [early endosome membrane]
Physical Entity
ZFYVE9-1 [early endosome membrane]
Activity
protein binding (0005515)
Orthologous Events
An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3 (Bos taurus)
An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3 (Canis familiaris)
An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3 (Danio rerio)
An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3 (Mus musculus)
An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3 (Rattus norvegicus)
Authored
Heldin, CH  (2006-02-02)
Moustakas, A  (2006-02-02)
Huminiecki, L  (2006-02-02)
Jassal, B  (2006-02-02)
Reviewed
Heldin, CH  (2006-04-18)
Huang, T  (2012-05-14)
Created
Jassal, B  (2006-01-18)