At the onset of mitosis, cyclin B is phosphorylated in the CRS sequence which creates a nuclear import signal in the amino terminus. The kinase(s) responsible for this phosphorylation are not yet known (Hagting et al., 1999).
Hagting, A, Jackman, M, Simpson, K, Pines, J
protein serine/threonine kinase activity of CRS kinase [cytosol]
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