Reactome | Translocation of Cyclin B1:phospho-Cdc2 to the cytoplasm

Translocation of Cyclin B1:phospho-Cdc2 to the cytoplasm

Stable Identifier

R-HSA-170072

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nuclear envelope

ReviewStatus

5/5

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Translocation of Cyclin B1:phospho-Cdc2 to the cytoplasm

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During interphase, cyclin B1 shuttles continuously in and out of the nucleus. The cyclin B cytoplasmic retention sequence (CRS), which is responsible for its interphase cytoplasmic localization, functions as a nuclear export sequence (Yang et al., 1998).

Literature References

PubMed ID	Title	Journal	Year
9670027	MPF localization is controlled by nuclear export Pines, J, Hagting, A, Clute, P, Karlsson, C, Jackman, M	EMBO J	1998
9679058	Control of cyclin B1 localization through regulated binding of the nuclear export factor CRM1 Kornbluth, S, Powers, MA, Yang, J, Moore, JD, Brennan, J, Bardes, ES	Genes Dev	1998