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Secreted CD14 binds LPS
Stable Identifier
R-HSA-169719
Type
Reaction [transition]
Species
Homo sapiens
Compartment
extracellular region
ReviewStatus
5/5
Locations in the PathwayBrowser
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Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
Transfer of LPS from LBP carrier to CD14 (Homo sapiens)
Secreted CD14 binds LPS (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
At the beginning of this reaction, 1 molecule of 'Secreted form of CD14', and 1 molecule of 'LBP complexed with bacterial LPS' are present. At the end of this reaction, 1 molecule of 'LBP', and 1 molecule of 'LPS complexed with secreted CD14' are present.
Literature References
PubMed ID
Title
Journal
Year
9665271
LPS-binding proteins and receptors
Fenton, MJ
,
Golenbock, DT
J Leukoc Biol
1998
Participants
Input
CD14(20-345) [extracellular region]
(Homo sapiens)
LBP:bacterial LPS [extracellular region]
(Homo sapiens)
Output
LBP [extracellular region]
(Homo sapiens)
LPS:secreted CD14 [extracellular region]
(Homo sapiens)
Participates
as an event of
Transfer of LPS from LBP carrier to CD14 (Homo sapiens)
Orthologous Events
Secreted CD14 binds LPS (Bos taurus)
Secreted CD14 binds LPS (Canis familiaris)
Secreted CD14 binds LPS (Gallus gallus)
Secreted CD14 binds LPS (Mus musculus)
Secreted CD14 binds LPS (Rattus norvegicus)
Secreted CD14 binds LPS (Sus scrofa)
Authored
de Bono, B (2005-08-16)
Reviewed
Gillespie, ME (2010-11-30)
Granucci, F (2012-11-13)
Zanoni, I (2012-11-13)
Gay, NJ (2006-04-24)
Created
de Bono, B (2005-12-06)
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