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RNP association
Stable Identifier
R-HSA-168895
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Influenza A virus
Compartment
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
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Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
Influenza Infection (Homo sapiens)
Virus Assembly and Release (Homo sapiens)
Packaging of Eight RNA Segments (Homo sapiens)
RNP association (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The random incorporation model as its name suggests proposes that there is no selection at all on which vRNPs are packaged. It is assumed that each vRNP has equal probability of being packaged, and that if enough vRNPS are packaged a particular percentage of budding virions will receive at least one copy of each genome segment. This model is supported by evidence that infectious virions may possess more than eight vRNPs assuring the presence of a full complement of eight vRNPs in a significant percentage of virus particles. Mathematical analysis of packaging suggested that twelve RNA segments would need to be packaged in order to obtain approximately 10% of virus particles that are fully infectious (Enami, 1991), a number that is compatible with experimental data (Donald, 1954). Due to the low amount of RNA per virion (estimated at 1-2% w/w), enumeration of the precise number of RNAs packaged in a virion is difficult.
Literature References
PubMed ID
Title
Journal
Year
13174769
Counts of influenza virus particles
ISAACS, A
,
DONALD, HB
J Gen Microbiol
1954
1833874
An influenza virus containing nine different RNA segments
Benham, C
,
Sharma, G
,
Palese, P
,
Enami, M
Virology
1991
Participants
Input
Segment 1 RNP [cytosol]
(Influenza A virus)
Segment 2 RNP [cytosol]
(Influenza A virus)
Segment 3 RNP [cytosol]
(Influenza A virus)
Segment 4 RNP [cytosol]
(Influenza A virus)
Segment 5 RNP [cytosol]
(Influenza A virus)
Segment 6 RNP [cytosol]
(Influenza A virus)
Segment 7 RNP [cytosol]
(Influenza A virus)
Segment 8 RNP [cytosol]
(Influenza A virus)
Output
RNP pre-assembly complex [cytosol]
(Influenza A virus)
Participates
as an event of
Packaging of Eight RNA Segments (Homo sapiens)
Event Information
Go Biological Process
viral genome packaging (0019072)
Disease
Name
Identifier
Synonyms
influenza
DOID:8469
Influenza with other manifestations (disorder), Influenza with other manifestations NOS (disorder), flu, Influenza with other manifestations, Influenza with non-respiratory manifestation (disorder), influenza with non-respiratory manifestation
Authored
Marsh, G (2007-05-01)
Reviewed
Squires, B (2007-05-01)
Rush, MG (2007-05-01)
Created
© 2025
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