Reactome | iE-DAP elicits a NOD1 response

iE-DAP elicits a NOD1 response

Stable Identifier

R-HSA-168400

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Early studies suggested that NOD1 and NOD2 responded to lipopolysaccharides (LPS), but this was later shown to be due to contamination of LPS with bacterial peptidoglycans (PGNs), the true elicitor for NODs. It is generally believed that PGNs bind NOD1 though this remains to be formally demonstrated. NOD1 senses PGN moieties with a minimal dipeptide structure of D-gamma-glutamyl-meso-diaminopimelic acid (iE-DAP), which is unique to PGN structures from all Gram-negative bacteria and certain Gram-positive bacteria, including the genus Listeria and Bacillus. Attachment of acyl residues enhances NOD1 stimulation several hundred fold, possibly by facilitating PGN entry into the cell (Hasegawa et al. 2007).

Literature References

PubMed ID	Title	Journal	Year
12796777	An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acid Chamaillard, M, Hashimoto, M, Horie, Y, Masumoto, J, Qiu, S, Saab, L, Ogura, Y, Kawasaki, A, Fukase, K, Kusumoto, S, Valvano, MA, Foster, SJ, Mak, TW, Nunez, G, Inohara, N	Nat Immunol	2003
12791997	Nod1 detects a unique muropeptide from gram-negative bacterial peptidoglycan Girardin, SE, Boneca, IG, Carneiro, LA, Antignac, A, Jéhanno, M, Viala, J, Tedin, K, Taha, MK, Labigne, A, Zähringer, U, Coyle, AJ, DiStefano, PS, Bertin, J, Sansonetti, PJ, Philpott, DJ	Science	2003