Docking and transport of the RNP:Karyopherin complex through the nuclear pore

Stable Identifier
R-HSA-168337
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Influenza A virus
Compartment
cytosol, nucleoplasm
ReviewStatus
5/5
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Docking and transport of the RNP:Karyopherin complex through the nuclear pore
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
These RNPs (10-20nm wide) are too large to passively diffuse into the nucleus and therefore, once released from an incoming particle they must rely on the active import mechanism of the host cell nuclear pore complex (NPC). Once the RNP heterodimeric karyopherin complex docks at the NPC, it is transported into the nucleus.
Literature References
PubMed ID Title Journal Year
1985200 Two signals mediate nuclear localization of influenza virus (A/WSN/33) polymerase basic protein 2

Nayak, DP, Mukaigawa, J

J Virol 1991
Participants
Input
Output
Participates
as an event of
Event Information
Go Biological Process
intracellular transport of virus (0075733)
This event is regulated
Requirements
Disease
Name Identifier Synonyms
influenza DOID:8469 Influenza with other manifestations (disorder), Influenza with other manifestations NOS (disorder), flu, Influenza with other manifestations, Influenza with non-respiratory manifestation (disorder), influenza with non-respiratory manifestation
Authored
Gillespie, ME  (2005-11-14)
Reviewed
Squires, B  (2006-10-29)
Created
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