Virion-associated M2 protein mediated ion infusion

Stable Identifier
Reaction [transition]
Homo sapiens
Related Species
Influenza A virus
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The uncoating of influenza viruses in endosomes is blocked by changes in pH caused by weak bases (e.g. ammonium chloride and chloroquine) or ionophores (e.g. monensin). Effective uncoating is also dependent on the presence of the viral M2 ion channel protein. Early on it was recognized that amantadine and rimantadine inhibit replication immediately following virus infection. Later it was found that the virus-associated M2 protein allows the influx of H+ ions from the endosome into the virion. This disrupts protein-protein interactions, resulting in the release of viral RNP free of the viral matrix (M1) protein. Amantadine and rimantadine have been shown to block the ion channel activity of the M2 protein and thus uncoating.
Literature References
PubMed ID Title Journal Year
7688826 Ion channel activity of influenza A virus M2 protein: characterization of the amantadine block

Lamb, RA, Wang, C, Pinto, LH, Takeuchi, K

J Virol 1993
Event Information
Go Biological Process
Catalyst Activity

proton transmembrane transporter activity of Influenza A Viral Particle Docked At The Endocytic Vesicle Membrane With An Open Pore [endocytic vesicle membrane]

Name Identifier Synonyms
influenza DOID:8469 Influenza with other manifestations (disorder), Influenza with other manifestations NOS (disorder), flu, Influenza with other manifestations, Influenza with non-respiratory manifestation (disorder), influenza with non-respiratory manifestation
Cite Us!