Virion-associated M2 protein mediated ion infusion

Stable Identifier
R-HSA-168313
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Influenza A virus
Compartment
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The uncoating of influenza viruses in endosomes is blocked by changes in pH caused by weak bases (e.g. ammonium chloride and chloroquine) or ionophores (e.g. monensin). Effective uncoating is also dependent on the presence of the viral M2 ion channel protein. Early on it was recognized that amantadine and rimantadine inhibit replication immediately following virus infection. Later it was found that the virus-associated M2 protein allows the influx of H+ ions from the endosome into the virion. This disrupts protein-protein interactions, resulting in the release of viral RNP free of the viral matrix (M1) protein. Amantadine and rimantadine have been shown to block the ion channel activity of the M2 protein and thus uncoating.

Literature References
PubMed ID Title Journal Year
7688826 Ion channel activity of influenza A virus M2 protein: characterization of the amantadine block

Wang, C, Takeuchi, K, Pinto, LH, Lamb, RA

J Virol 1993
Participants
Participant Of
Event Information
Go Biological Process
Catalyst Activity
Catalyst Activity
Title
transporter activity of Influenza A Viral Particle Docked At The Endocytic Vesicle Membrane With An Open Pore [endocytic vesicle membrane]
Physical Entity
Activity
Disease
Name Identifier Synonyms
influenza 8469 Influenza with other manifestations (disorder), Influenza with other manifestations NOS (disorder), flu, Influenza with other manifestations, Influenza with non-respiratory manifestation (disorder), influenza with non-respiratory manifestation
Created
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