Recognition of the Nuclear Localization Signal (NLS) by a Karyopherin Alpha Family Protein

Stable Identifier
R-HSA-168297
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Influenza A virus
Compartment
cytosol
ReviewStatus
5/5
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Recognition of the Nuclear Localization Signal (NLS) by a Karyopherin Alpha Family Protein
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The eight influenza virus genome segments never exist as naked RNA but are associated with four viral proteins to form viral ribonucleoprotein complexes (vRNPs). The major viral protein in the RNP complex is the nucleocapsid protein (NP), which coats the RNA. The remaining proteins PB1, PB2 and PA bind to the partially complementary ends of the viral RNA, creating the distinctive panhandle structure. The influenza viral NP behaves like a nuclear localization sequence (NLS) containing protein. The RNP docks at the nuclear envelope only in the presence of the heterodimeric karyopherin alpha and beta complex. Here karyopherin alpha recognizes the RNP.

Literature References
PubMed ID Title Journal Year
15702989 An unconventional NLS is critical for the nuclear import of the influenza A virus nucleoprotein and ribonucleoprotein

Garcia-Sastre, A, Palese, P, Cros, JF

Traffic 2005
7559393 Nuclear import of influenza virus RNA can be mediated by viral nucleoprotein and transport factors required for protein import

Moroianu, J, Blobel, G, Palese, P, Jaskunas, R, O'Neill, RE

J Biol Chem 1995
Participants
Input
Output
Participates
as an event of
Event Information
Go Biological Process
intracellular transport of virus (0075733)
Disease
Name Identifier Synonyms
influenza DOID:8469 Influenza with other manifestations (disorder), Influenza with other manifestations NOS (disorder), flu, Influenza with other manifestations, Influenza with non-respiratory manifestation (disorder), influenza with non-respiratory manifestation
Authored
Gillespie, ME  (2005-11-14)
Reviewed
Squires, B  (2006-10-29)
Created
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