Priming and Initiation of Transcription

Stable Identifier
R-HSA-168280
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Influenza A virus
Compartment
nucleoplasm
ReviewStatus
5/5
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Priming and Initiation of Transcription
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The host cell mRNA bound to viral RNA polymerase PB2 subunit is cleaved by the viral RNA polymerase PB1 subunit's endonuclease activity, and the capped 5' end plus 10-13 nucleotides of the host mRNA remains bound to the polymerase complex (Plotch, 1981; Krug, 1981; Hagen, 1994; Cianci, 1995, Li, 1998; Li, 2001). Viral mRNA may be protected against cap-snatching by the polymerase complex itself, which tightly binds capped viral mRNA (Shih, 1996). A guanine residue, complementary to a cytosine in the vRNA, is added to the host-derived cap, catalyzed by the RNA polymerase activity of the PB1 viral RNA polymerase subunit (Beaton, 1981; Toyoda, 1986).
Literature References
Participants
Input
Output
Participates
as an event of
Event Information
Go Biological Process
viral transcription (0019083)
Catalyst Activity

RNA-directed RNA polymerase activity of Viral Polymerase [nucleoplasm]

Physical Entity
Viral Polymerase [nucleoplasm] (Influenza A virus)
Activity
RNA-directed RNA polymerase activity (GO:0003968)
Disease
Name Identifier Synonyms
influenza DOID:8469 Influenza with other manifestations (disorder), Influenza with other manifestations NOS (disorder), flu, Influenza with other manifestations, Influenza with non-respiratory manifestation (disorder), influenza with non-respiratory manifestation
Cross References
Mondo
Authored
Bortz, E  (2007-02-13)
Garcia-Sastre, A  (2007-02-13)
Reviewed
Squires, B  (2007-02-13)
Created
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