TLR9 processing at neutral pH

Stable Identifier
R-HSA-1678981
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

TLR9 traffics to an endosomal vesicle where it is processed by cathepsin S at neural pH to generate an N-terminal product (TLR9 N-ter, aa 1-723). The N-terminal fragment of TLR9 also binds ligand, but in contrast to the C-terminal fragment it inhibits TLR9 signaling. Thus, a proper balance between the two proteolytic events probably regulates TLR9-mediated host responses. (Chockalingam A et al 2011).

Literature References
PubMed ID Title Journal Year
21604257 Negative regulation of signaling by a soluble form of toll-like receptor 9

Chockalingam, A, Cameron, JL, Brooks, JC, Leifer, CA

Eur J Immunol 2011
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
cysteine-type endopeptidase activity of CTSS-like proteins [endolysosome lumen]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created