TLR9 processing at neutral pH

Stable Identifier
R-HSA-1678981
Type
Reaction [transition]
Species
Homo sapiens
Compartment
endolysosome membrane
ReviewStatus
5/5
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TLR9 processing at neutral pH
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TLR9 traffics to an endosomal vesicle where it is processed by cathepsin S at neural pH to generate an N-terminal product (TLR9 N-ter, aa 1-723). The N-terminal fragment of TLR9 also binds ligand, but in contrast to the C-terminal fragment it inhibits TLR9 signaling. Thus, a proper balance between the two proteolytic events probably regulates TLR9-mediated host responses. (Chockalingam A et al 2011).
Literature References
PubMed ID Title Journal Year
21604257 Negative regulation of signaling by a soluble form of toll-like receptor 9

Cameron, JL, Brooks, JC, Chockalingam, A, Leifer, CA

Eur J Immunol 2011
Participants
Input
Output
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as an event of
Catalyst Activity

cysteine-type endopeptidase activity of CTSS-like proteins [endolysosome lumen]

Physical Entity
CTSS-like proteins [endolysosome lumen] (Homo sapiens)
Activity
cysteine-type endopeptidase activity (GO:0004197)
Orthologous Events
TLR9 processing at neutral pH (Bos taurus)
TLR9 processing at neutral pH (Canis familiaris)
TLR9 processing at neutral pH (Mus musculus)
TLR9 processing at neutral pH (Rattus norvegicus)
TLR9 processing at neutral pH (Sus scrofa)
Authored
Shamovsky, V  (2011-10-19)
Reviewed
Rose II, WA  (2012-02-28)
Leifer, CA  (2012-02-28)
Gillespie, ME  (2012-02-09)
Created
Shamovsky, V  (2011-10-19)
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