Reactome | AP1M2 [cytosol]

AP1M2 [cytosol]

Stable Identifier

R-HSA-167699

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

AP-1 mu 2

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - HIV Infection (Homo sapiens)
      - Host Interactions of HIV factors (Homo sapiens)
        
        The role of Nef in HIV-1 replication and disease pathogenesis (Homo sapiens)
        
        Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters (Homo sapiens)
        
        Nef mediated downregulation of MHC class I complex cell surface expression (Homo sapiens)
        
        Degradation of MHC I Complex (Homo sapiens)
        
        AP-1 Complex [cytosol] (Homo sapiens)
        
        AP-1 mu [cytosol] (Homo sapiens)
        
        AP1M2 [cytosol] (Homo sapiens)
        
        Nef:class I MHC complex:AP-1:PACS-1 Complex [early endosome membrane] (Homo sapiens)
        
        AP-1 Complex [cytosol] (Homo sapiens)
        
        AP-1 mu [cytosol] (Homo sapiens)
        
        AP1M2 [cytosol] (Homo sapiens)
        
        Formation of MHC I:Nef:AP-1:PACS-1 Complex (Homo sapiens)
        
        AP-1 Complex [cytosol] (Homo sapiens)
        
        AP-1 mu [cytosol] (Homo sapiens)
        
        AP1M2 [cytosol] (Homo sapiens)
        
        Nef:class I MHC complex:Ap-1:PACS-1 Complex [Golgi membrane] (Homo sapiens)
        
        AP-1 Complex [cytosol] (Homo sapiens)
        
        AP-1 mu [cytosol] (Homo sapiens)
        
        AP1M2 [cytosol] (Homo sapiens)
        
        Transport of MHC I:Nef:AP-1:PACS-1 Complex (Homo sapiens)
        
        Nef:class I MHC complex:AP-1:PACS-1 Complex [early endosome membrane] (Homo sapiens)
        
        AP-1 Complex [cytosol] (Homo sapiens)
        
        AP-1 mu [cytosol] (Homo sapiens)
        
        AP1M2 [cytosol] (Homo sapiens)
        
        Nef:class I MHC complex:Ap-1:PACS-1 Complex [Golgi membrane] (Homo sapiens)
        
        AP-1 Complex [cytosol] (Homo sapiens)
        
        AP-1 mu [cytosol] (Homo sapiens)
        
        AP1M2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9Y6Q5 AP1M2

Gene Names

AP1M2

Chain

chain:1-423

Reference Genes

BioGPS Gene:10053 AP1M2

COSMIC (genes):AP1M2 AP1M2

CTD Gene:10053 AP1M2

dbSNP Gene:10053 AP1M2

ENSEMBL:ENSG00000129354 AP1M2

ENSEMBL_homo_sapiens_GENE:ENSG00000129354.12 AP1M2

HGNC:558 AP1M2

KEGG Gene (Homo sapiens):10053 AP1M2

Monarch:10053 AP1M2

NCBI Gene:10053 AP1M2

OMIM:607309 AP1M2

UCSC:Q9Y6Q5 AP1M2

Reference Transcript

Other Identifiers

10053

11717062_at

16868797

218261_PM_at

218261_at

3850458

3850459

3850461

3850462

3850463

3850465

3850466

3850467

3850468

3850469

3850470

3850471

3850472

3850476

3850479

3850480

45507_f_at

65517_PM_at

65517_at

8034084

GE58371

GO:0000139

GO:0005515

GO:0005764

GO:0005765

GO:0005773

GO:0005794

GO:0005829

GO:0006605

GO:0006886

GO:0006903

GO:0015031

GO:0016020

GO:0016192

GO:0030121

GO:0030131

GO:0030136

GO:0030659

GO:0030665

GO:0031410

GO:0032588

GO:0035615

GO:0043226

GO:0043231

GO:0060090

GO:0110010

HMNXSV003057070

ILMN_1705861

PH_hs_0001667

TC19001171.hg

g9506796_3p_s_at

Participates

as a member of

AP-1 mu [cytosol] (Homo sapiens)

Other forms of this molecule

AP1M2 [cytoplasmic vesicle membrane]

AP1M2 [Golgi membrane]

AP1M2 [lysosomal membrane]

AP1M2 [trans-Golgi network membrane]

Inferred To

Homologues of AP1M2 [cytosol] (Caenorhabditis elegans)

AP-1mu [cytosol] (Drosophila melanogaster)

unc-101 [cytosol] (Caenorhabditis elegans)

ap1m2 [cytosol] (Danio rerio)

ap1m2 [cytosol] (Xenopus tropicalis)

apm-1 [cytosol] (Caenorhabditis elegans)

Ap1m2 [cytosol] (Mus musculus)

Ap1m2 [cytosol] (Rattus norvegicus)

apm1 [cytosol] (Dictyostelium discoideum)

apm1 [cytosol] (Schizosaccharomyces pombe)

AP1M2 [cytosol] (Bos taurus)

AP1M2 [cytosol] (Canis familiaris)

AP1M2 [cytosol] (Plasmodium falciparum)

AP1M2 [cytosol] (Sus scrofa)

APM1 [cytosol] (Saccharomyces cerevisiae)

Cross References

RefSeq

NP_001287816.1, NP_005489.2

OpenTargets

ENSG00000129354

GeneCards

Q9Y6Q5

HPA

ENSG00000129354-AP1M2

Ensembl

ENSP00000465685, ENST00000250244, ENST00000590923, ENSG00000129354, ENSP00000250244

PRO

Q9Y6Q5

Pharos - Targets

Q9Y6Q5