Binding of PLCG1 to active TrkA receptor

Stable Identifier
R-HSA-167674
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, extracellular region
ReviewStatus
5/5
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Binding of PLCG1 to active TrkA receptor
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The PLC-gamma 1 docking site in Trk receptor (Y785) is important for initiation and maintenance of hippocampal LTP (long term potentiation); this residue in TrkA receptor also binds to CHK tyrosine kinase, which participates in MAPK pathway activation and is involved in PC12 cells neurite outgrowth in response to NGF. PLC-gamma 1 activation results in long term induction of a sodium channel gene (PN1).
Participants
Input
Output
Participates
as an event of
Inferred From
Binding of Plcg1 to active Trk receptor (Rattus norvegicus)
Authored
Nasi, S  (2006-10-10)
Annibali, D  (2006-10-10)
Reviewed
Greene, LA  (2007-11-08)
Created
Jassal, B  (2005-11-01)
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