PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane

Stable Identifier
Reaction [transition]
Homo sapiens
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At the plasma membrane, phosphatidylinositol-4-phosphate 5-kinase type-1 alpha (PIP5K1A), beta (PIP5K1B), and gamma (PIP5K1C) phosphorylate phosphatidylinositol 4-phosphate (PI4P) to produce phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2).

The following lists the above proteins with their corresponding literature references: PIP5K1A (Halstead et al. 2006, Zhang et al. 1997), PIP5K1B (Zhang et al. 1997), and PIP5K1C (Di Paolo et al. 2002).

This reaction is of particular interest because its regulation by small GTPases of the RHO and ARF families, not yet annotated here, ties the process of phosphatidylinositol phosphate biosynthesis to regulation of the actin cytoskeleton and vesicular trafficking, and hence to diverse aspects of cell motility and signalling (Oude Weernink et al. 2004, 2007).
Literature References
PubMed ID Title Journal Year
15464023 Regulation and cellular roles of phosphoinositide 5-kinases

Schmidt, M, Jakobs, KH, Oude Weernink, PA

Eur J Pharmacol 2004
17245604 Phospholipase D signaling: orchestration by PIP2 and small GTPases

Schmidt, M, Oude Weernink, PA, López de Jesús, M

Naunyn Schmiedebergs Arch Pharmacol 2007
9211928 Phosphatidylinositol-4-phosphate 5-kinase isozymes catalyze the synthesis of 3-phosphate-containing phosphatidylinositol signaling molecules

Thum, O, Majerus, PW, Parker, GJ, Boronenkov, IV, Zhang, X, Prestwich, GD, Anderson, RA, Loijens, JC, Chen, J, Norris, FA

J Biol Chem 1997
12422219 Recruitment and regulation of phosphatidylinositol phosphate kinase type 1 gamma by the FERM domain of talin

Cestra, G, Pellegrini, L, Di Paolo, G, Zoncu, R, Letinic, K, Wenk, MR, Voronov, S, De Camilli, P, Guo, J, Chang, S

Nature 2002
16979564 A role for PtdIns(4,5)P2 and PIP5Kalpha in regulating stress-induced apoptosis

Jalink, K, Heck, AJ, Mohammed, S, Halstead, JR, Meeuws, S, Divecha, N, D'Santos, CS, Snel, MH, van Rheenen, J

Curr Biol 2006
Catalyst Activity

1-phosphatidylinositol-4-phosphate 5-kinase activity of PIP5K1A-C [cytosol]

Orthologous Events
Cross References
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