Reactome | PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane

PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane

Stable Identifier

R-HSA-1676024

Type

Reaction [transition]

Species

Homo sapiens

Compartment

late endosome membrane, cytosol

ReviewStatus

5/5

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PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane

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At the late endosome membrane, phosphatidylinositol 3-kinase catalytic subunit type 3 (PIK3C3) aka VPS34 binds to phosphoinositide 3-kinase regulatory subunit 4 (PIK3R4). The PIK3C3:PIK3R4 complex and phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit alpha (PIK3C2A) phosphorylate phosphatidylinositol (PI) to phosphatidylinositol 3-phosphate (PI3P).

The following lists the above proteins with their corresponding literature references: PIK3C3:PIK3R4 (Panaretou et al. 1997, Volinia et al. 1995, Cao et al. 2007) and PIK3C2A (Arcaro et al. 2000, Domin et al. 2000).

Literature References

PubMed ID	Title	Journal	Year
7628435	A human phosphatidylinositol 3-kinase complex related to the yeast Vps34p-Vps15p protein sorting system Volinia, S, Dhand, R, Vanhaesebroeck, B, MacDougall, LK, Stein, R, Zvelebil, MJ, Domin, J, Panaretou, C, Waterfield, MD	EMBO J	1995
8999962	Characterization of p150, an adaptor protein for the human phosphatidylinositol (PtdIns) 3-kinase. Substrate presentation by phosphatidylinositol transfer protein to the p150.Ptdins 3-kinase complex Panaretou, C, Domin, J, Cockcroft, S, Waterfield, MD	J Biol Chem	1997
10805725	Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors Arcaro, A, Zvelebil, MJ, Wallasch, C, Ullrich, A, Waterfield, MD, Domin, J	Mol Cell Biol	2000
10766823	The class II phosphoinositide 3-kinase PI3K-C2alpha is concentrated in the trans-Golgi network and present in clathrin-coated vesicles Domin, J, Gaidarov, I, Smith, ME, Keen, JH, Waterfield, MD	J Biol Chem	2000
17651088	Myotubularin lipid phosphatase binds the hVPS15/hVPS34 lipid kinase complex on endosomes Cao, C, Laporte, J, Backer, JM, Wandinger-Ness, A, Stein, MP	Traffic	2007