Reactome | Formation of the HIV-1 Early Elongation Complex

Formation of the HIV-1 Early Elongation Complex

Stable Identifier

R-HSA-167158

Type

Pathway

Species

Homo sapiens

Related Species

Human immunodeficiency virus 1

Compartment

nucleoplasm

ReviewStatus

5/5

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Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - HIV Infection (Homo sapiens)
      - HIV Life Cycle (Homo sapiens)
        
        Late Phase of HIV Life Cycle (Homo sapiens)
        
        Transcription of the HIV genome (Homo sapiens)
        
        HIV Transcription Elongation (Homo sapiens)
        
        Formation of the HIV-1 Early Elongation Complex (Homo sapiens)

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Formation of the HIV-1 Early Elongation Complex

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This HIV-1 event was inferred from the corresponding human RNA Poll II transcription event. The details relevant to HIV-1 are described below. Formation of the early elongation complex involves hypophosphorylation of RNA Pol II CTD by FCP1P protein, association of the DSIF complex with RNA Pol II, and formation of DSIF:NELF:HIV-1 early elongation complex as described below (Mandal et al 2002; Kim et al 2003; Yamaguchi et al 2002).

Literature References

PubMed ID	Title	Journal	Year
12653964	Structure-function analysis of human Spt4: evidence that hSpt4 and hSpt5 exert their roles in transcriptional elongation as parts of the DSIF complex. Furuya, A, Sato, H, Kim, DK, Yamada, T, Wada, T, Handa, H, Inukai, N, Yamaguchi, Y	Genes Cells	2003
12370301	FCP1, a phosphatase specific for the heptapeptide repeat of the largest subunit of RNA polymerase II, stimulates transcription elongation. Mandal, SS, Reinberg, D, Cabane, K, Cho, H, Kim, S	Mol Cell Biol	2002
11940650	Evidence that negative elongation factor represses transcription elongation through binding to a DRB sensitivity-inducing factor/RNA polymerase II complex and RNA. Wada, T, Handa, H, Inukai, N, Narita, T, Yamaguchi, Y	Mol Cell Biol	2002

Participants

Events

Participates

as an event of

HIV Transcription Elongation (Homo sapiens)

Inferred From

Formation of the Early Elongation Complex (Homo sapiens)

Disease

Name	Identifier	Synonyms
Human immunodeficiency virus infectious disease	DOID:526	HIV infection

Authored

Matthews, L (2005-07-27)

Rice, AP (2005-07-27)

Created

Matthews, L (2005-10-11)

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