Reactome | MBL2 trimer [extracellular region]

MBL2 trimer [extracellular region]

Stable Identifier

R-HSA-166675

Type

Complex

Species

Homo sapiens

Compartment

extracellular region

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - SARS-CoV Infections (Homo sapiens)
      - SARS-CoV-2 Infection (Homo sapiens)
        
        SARS-CoV-2-host interactions (Homo sapiens)
        
        SARS-CoV-2 activates/modulates innate and adaptive immune responses (Homo sapiens)
        
        SARS-CoV-2 N binds MASP2 (Homo sapiens)
        
        MBL2 dodecamer:MASP1 dimer:MASP2-1 dimer [extracellular region] (Homo sapiens)
        
        MBL2 dodecamer [extracellular region] (Homo sapiens)
        
        MBL2 trimer [extracellular region] (Homo sapiens)
        
        N:MBL2 dodecamer:MASP1 dimer:MASP2-1 dimer [extracellular region] (Homo sapiens)
        
        MBL2 dodecamer [extracellular region] (Homo sapiens)
        
        MBL2 trimer [extracellular region] (Homo sapiens)

Immune System (Homo sapiens)

- Innate Immune System (Homo sapiens)
  - Complement cascade (Homo sapiens)
    - Initial triggering of complement (Homo sapiens)
      - Conversion of C2 into C2a and C2b (Homo sapiens)
        
        C4 activators [plasma membrane] (Homo sapiens)
        
        MBL2,FCN:activated MASPs:carbohydrate patterns [plasma membrane] (Homo sapiens)
        
        MBL:activated MASPs:mannose-based carbohydrates [plasma membrane] (Homo sapiens)
        
        MBL2 dodecamer:2xActivated MASP1:2xActivated MASP2-1 [extracellular region] (Homo sapiens)
        
        MBL2 dodecamer [extracellular region] (Homo sapiens)
        
        MBL2 trimer [extracellular region] (Homo sapiens)
      - Conversion of C4 into C4a and C4b (Homo sapiens)
        
        C4 activators [plasma membrane] (Homo sapiens)
        
        MBL2,FCN:activated MASPs:carbohydrate patterns [plasma membrane] (Homo sapiens)
        
        MBL:activated MASPs:mannose-based carbohydrates [plasma membrane] (Homo sapiens)
        
        MBL2 dodecamer:2xActivated MASP1:2xActivated MASP2-1 [extracellular region] (Homo sapiens)
        
        MBL2 dodecamer [extracellular region] (Homo sapiens)
        
        MBL2 trimer [extracellular region] (Homo sapiens)
      - Creation of C4 and C2 activators (Homo sapiens)
        
        Lectin pathway of complement activation (Homo sapiens)
        
        Activation of MASPs (Homo sapiens)
        
        MBL2,FCN:MASPs:carbohydrate patterns [plasma membrane] (Homo sapiens)
        
        MBL2 dodecamer:MASP1 dimer:MASP2-1 dimer:Bacterial mannose surface pattern:4xCa2+ [plasma membrane] (Homo sapiens)
        
        MBL2 dodecamer:MASP1 dimer:MASP2-1 dimer [extracellular region] (Homo sapiens)
        
        MBL2 dodecamer [extracellular region] (Homo sapiens)
        
        MBL2 trimer [extracellular region] (Homo sapiens)
        
        MBL2,FCN:activated MASPs:carbohydrate patterns [plasma membrane] (Homo sapiens)
        
        MBL:activated MASPs:mannose-based carbohydrates [plasma membrane] (Homo sapiens)
        
        MBL2 dodecamer:2xActivated MASP1:2xActivated MASP2-1 [extracellular region] (Homo sapiens)
        
        MBL2 dodecamer [extracellular region] (Homo sapiens)
        
        MBL2 trimer [extracellular region] (Homo sapiens)
        
        MBL binds to repetitive carbohydrate structures on the surfaces of viruses, bacteria, fungi, and protozoa (Homo sapiens)
        
        MBL2 dodecamer:MASP1 dimer:MASP2-1 dimer [extracellular region] (Homo sapiens)
        
        MBL2 dodecamer [extracellular region] (Homo sapiens)
        
        MBL2 trimer [extracellular region] (Homo sapiens)
        
        MBL2 dodecamer:MASP1 dimer:MASP2-1 dimer:Bacterial mannose surface pattern:4xCa2+ [plasma membrane] (Homo sapiens)
        
        MBL2 dodecamer:MASP1 dimer:MASP2-1 dimer [extracellular region] (Homo sapiens)
        
        MBL2 dodecamer [extracellular region] (Homo sapiens)
        
        MBL2 trimer [extracellular region] (Homo sapiens)

Literature References

PubMed ID	Title	Journal	Year
15728497	The two major oligomeric forms of human mannan-binding lectin: chemical characterization, carbohydrate-binding properties, and interaction with MBL-associated serine proteases Arlaud, GJ, Teillet, F, Dublet, B, Andrieu, JP, Thielens, NM, Gaboriaud, C	J Immunol	2005

Participants

components

x 3 MBL2 [extracellular region] (Homo sapiens)

Participates

as a component of

MBL2 dodecamer [extracellular region] (Homo sapiens)

Inferred To

MBL2 trimer [extracellular region] (Bos taurus)

MBL2 trimer [extracellular region] (Danio rerio)

MBL2 trimer [extracellular region] (Gallus gallus)

MBL2 trimer [extracellular region] (Mus musculus)

MBL2 trimer [extracellular region] (Rattus norvegicus)

MBL2 trimer [extracellular region] (Sus scrofa)

MBL2 trimer [extracellular region] (Xenopus tropicalis)