IRAK4 binds to the activated TLR receptor:TIRAP:MyD88 complex

Stable Identifier
R-HSA-166082
Type
Reaction
Species
Homo sapiens
Related Species
Chlamydia trachomatis, Neisseria meningitidis serogroup B
Compartment
plasma membrane, cytosol
Synonyms
IRAK4 binds to the activated TLR receptor:MAL:MyD88 complex
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IRAK4 binds to the activated TLR receptor:TIRAP:MyD88 complex
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IRAK4 is the mammalian homolog of Drosophila melanogaster Tube [Towb P et al 2009; Moncrieffe MC et al 2008]. Like Tube, IRAK4 possesses a conserved N-terminal death domain (DD), which mediates interactions with MyD88 at one binding site and a downstream IRAK kinase at the other, thereby bridging MyD88 and IRAK1/2 association [Towb P et al 2009; Lin SC e al 2010]. IRAK-4 plays a critical role in Toll receptor signaling - any interference with IRAK-4's kinase activity virtually abolishes downstream events. This is not the case with other members of the IRAK family [Suzuki N et al 2002; Li S et al 2002].

Literature References
PubMed ID Title Journal Year
12297423 IRAK-4 as the central TIR signaling mediator in innate immunity

Suzuki, S, Yeh, WC, Suzuki, N

Trends Immunol 2002
20485341 Helical assembly in the MyD88-IRAK4-IRAK2 complex in TLR/IL-1R signalling

Lo, YC, Lin, SC, Wu, H

Nature 2010
19498957 Tube Is an IRAK-4 homolog in a Toll pathway adapted for development and immunity

Wasserman, SA, Towb, P, Sun, H

J Innate Immun 2009
19592493 An oligomeric signaling platform formed by the Toll-like receptor signal transducers MyD88 and IRAK-4

Motshwene, PG, Sandercock, AM, Moncrieffe, MC, Kao, C, Latz, E, Grossmann, JG, Ayaluru, M, Robinson, CV, Gay, NJ

J Biol Chem 2009
18829464 Assembly of oligomeric death domain complexes during Toll receptor signaling

Gay, NJ, Moncrieffe, MC, Grossmann, JG

J. Biol. Chem. 2008
11960013 IRAK-4: a novel member of the IRAK family with the properties of an

Wesche, H, Li, S, Fontana, EJ, Strelow, A

Proc Natl Acad Sci U S A 2002
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Orthologous Events
IRAK4 recruitment to the activated TLR complexed with ligand, TIRAP and MyD88 (Gallus gallus)
Authored
de Bono, B  (2005-08-16)
Reviewed
Gillespie, ME  (2010-11-30)
Gay, NJ  (2006-04-24)
Napetschnig, J  (2012-11-16)
Created
de Bono, B  (2005-08-16)
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