IRAK4 binds to the activated TLR receptor:TIRAP:MyD88 complex

Stable Identifier
R-HSA-166082
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Chlamydia trachomatis, Neisseria meningitidis serogroup B
Compartment
plasma membrane, cytosol
Synonyms
IRAK4 binds to the activated TLR receptor:MAL:MyD88 complex
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
IRAK4 binds to the activated TLR receptor:TIRAP:MyD88 complex
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
IRAK4 is the mammalian homolog of Drosophila melanogaster Tube [Towb P et al 2009; Moncrieffe MC et al 2008]. Like Tube, IRAK4 possesses a conserved N-terminal death domain (DD), which mediates interactions with MyD88 at one binding site and a downstream IRAK kinase at the other, thereby bridging MyD88 and IRAK1/2 association [Towb P et al 2009; Lin SC e al 2010]. IRAK-4 plays a critical role in Toll receptor signaling - any interference with IRAK-4's kinase activity virtually abolishes downstream events. This is not the case with other members of the IRAK family [Suzuki N et al 2002; Li S et al 2002].
Literature References
PubMed ID Title Journal Year
12297423 IRAK-4 as the central TIR signaling mediator in innate immunity

Suzuki, N, Suzuki, S, Yeh, WC

Trends Immunol 2002
20485341 Helical assembly in the MyD88-IRAK4-IRAK2 complex in TLR/IL-1R signalling

Lin, SC, Lo, YC, Wu, H

Nature 2010
19498957 Tube Is an IRAK-4 homolog in a Toll pathway adapted for development and immunity

Towb, P, Sun, H, Wasserman, SA

J Innate Immun 2009
19592493 An oligomeric signaling platform formed by the Toll-like receptor signal transducers MyD88 and IRAK-4

Motshwene, PG, Moncrieffe, MC, Grossmann, JG, Kao, C, Ayaluru, M, Sandercock, AM, Robinson, CV, Latz, E, Gay, NJ

J Biol Chem 2009
18829464 Assembly of oligomeric death domain complexes during Toll receptor signaling

Moncrieffe, MC, Grossmann, JG, Gay, NJ

J. Biol. Chem. 2008
11960013 IRAK-4: a novel member of the IRAK family with the properties of an

Li, S, Strelow, A, Fontana, EJ, Wesche, H

Proc Natl Acad Sci U S A 2002
Participants
Input
Output
Participates
as an event of
Orthologous Events
IRAK4 recruitment to the activated TLR complexed with ligand, TIRAP and MyD88 (Gallus gallus)
Authored
de Bono, B  (2005-08-16)
Reviewed
Gay, NJ  (2006-04-24)
Gillespie, ME  (2010-11-30)
Napetschnig, J  (2012-11-16)
Created
de Bono, B  (2005-08-16)
Cite Us!