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GPI-bound CD14 binds LPS
Stable Identifier
R-HSA-166038
Type
Reaction [transition]
Species
Homo sapiens
Compartment
extracellular region
,
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
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Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
Transfer of LPS from LBP carrier to CD14 (Homo sapiens)
GPI-bound CD14 binds LPS (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
At the beginning of this reaction, 1 molecule of 'GPI-anchored form of CD14', and 1 molecule of 'LBP complexed with bacterial LPS' are present. At the end of this reaction, 1 molecule of 'LPS complexed with GPI-anchored CD14', and 1 molecule of 'LBP' are present.
Literature References
PubMed ID
Title
Journal
Year
9665271
LPS-binding proteins and receptors
Fenton, MJ
,
Golenbock, DT
J Leukoc Biol
1998
Participants
Input
GPIN-CD14(20-345) [plasma membrane]
(Homo sapiens)
LBP:bacterial LPS [extracellular region]
(Homo sapiens)
Output
LBP [extracellular region]
(Homo sapiens)
LPS:GPI-anchored CD14 [plasma membrane]
(Homo sapiens)
Participates
as an event of
Transfer of LPS from LBP carrier to CD14 (Homo sapiens)
Orthologous Events
GPI-bound CD14 binds LPS (Bos taurus)
GPI-bound CD14 binds LPS (Canis familiaris)
GPI-bound CD14 binds LPS (Gallus gallus)
GPI-bound CD14 binds LPS (Mus musculus)
GPI-bound CD14 binds LPS (Rattus norvegicus)
GPI-bound CD14 binds LPS (Sus scrofa)
Authored
de Bono, B (2005-08-16)
Reviewed
Gillespie, ME (2010-11-30)
Granucci, F (2012-11-13)
Zanoni, I (2012-11-13)
Gay, NJ (2006-04-24)
Created
de Bono, B (2005-08-16)
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