Reactome | Phosphorylation of 4E-BP1 by activated mTORC1

Phosphorylation of 4E-BP1 by activated mTORC1

Stable Identifier

R-HSA-165692

Type

Reaction [transition]

Species

Homo sapiens

Compartment

lysosomal membrane, cytosol

ReviewStatus

5/5

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Phosphorylation of 4E-BP1 by activated mTORC1

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Raptor recruits mTOR to non-phosphorylated 4E-BP1 bound to eIF4E and positively modulates phosphorylation of 4E-BP1 by mTOR. 4E-BP1 is further phosphorylated on multiple sites by other unknown kinases, also contributing to the dissociation of 4E-BP1 from eIF4E. Thus mTORC1 relieves the inhibitory effect of 4E-BP1 on eIF4E dependent translation initiation (Inoki et al. 2005, Gingras et al. 1999, 2001).

Literature References

PubMed ID	Title	Journal	Year
15809305	Structure of S6 kinase 1 determines whether raptor-mTOR or rictor-mTOR Ali, SM, Sabatini, DM	J Biol Chem	2005
12150926	Raptor, a binding partner of target of rapamycin (TOR), mediates TOR Hidayat, S, Yonezawa, K, Oshiro, N, Tokunaga, C, Avruch, J, Hara, K, Yoshino, K, Maruki, Y, Long, X	Cell	2002