S2P hydrolyzes SREBP1A,1C,2

Stable Identifier
R-HSA-1655851
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
S2P hydrolyzes SREBF1A,1C,2
Locations in the PathwayBrowser
Summation

S2P(MBTPS2), a membrane-bound protease in the Golgi, cleaves within the transmembrane region of SREBP1A/1C/2 (SREBF1A/1C/2), releasing the N-terminal domain of SREBP1A/1C/2 into the cytosol.

Literature References
PubMed ID Title Journal Year
8156598 SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis

Wang, X, Sato, R, Brown, MS, Hua, X, Goldstein, JL

Cell 1994
8674110 Sterol-regulated release of SREBP-2 from cell membranes requires two sequential cleavages, one within a transmembrane segment

Sakai, J, Duncan, EA, Rawson, RB, Hua, X, Brown, MS, Goldstein, JL

Cell 1996
9659902 Complementation cloning of S2P, a gene encoding a putative metalloprotease required for intramembrane cleavage of SREBPs

Rawson, RB, Zelenski, NG, Nijhawan, D, Ye, J, Sakai, J, Hasan, MT, Chang, TY, Brown, MS, Goldstein, JL

Mol Cell 1997
10805775 Asparagine-proline sequence within membrane-spanning segment of SREBP triggers intramembrane cleavage by site-2 protease

Ye, J, Davé, UP, Grishin, NV, Goldstein, JL, Brown, MS

Proc Natl Acad Sci U S A 2000
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
metalloendopeptidase activity of MBTPS2 [Golgi membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created