Reactome | S2P hydrolyzes SREBP1A,1C,2

S2P hydrolyzes SREBP1A,1C,2

Stable Identifier

R-HSA-1655851

Type

Reaction [transition]

Species

Homo sapiens

Compartment

Golgi membrane, cytosol

Synonyms

S2P hydrolyzes SREBF1A,1C,2

ReviewStatus

5/5

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S2P(MBTPS2), a membrane-bound protease in the Golgi, cleaves within the transmembrane region of SREBP1A/1C/2 (SREBF1A/1C/2), releasing the N-terminal domain of SREBP1A/1C/2 into the cytosol.

Literature References

PubMed ID	Title	Journal	Year
8674110	Sterol-regulated release of SREBP-2 from cell membranes requires two sequential cleavages, one within a transmembrane segment Brown, MS, Rawson, RB, Hua, X, Duncan, EA, Sakai, J, Goldstein, JL	Cell	1996
8156598	SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis Brown, MS, Wang, X, Goldstein, JL, Hua, X, Sato, R	Cell	1994
9659902	Complementation cloning of S2P, a gene encoding a putative metalloprotease required for intramembrane cleavage of SREBPs Brown, MS, Hasan, MT, Rawson, RB, Zelenski, NG, Ye, J, Nijhawan, D, Chang, TY, Sakai, J, Goldstein, JL	Mol Cell	1997
10805775	Asparagine-proline sequence within membrane-spanning segment of SREBP triggers intramembrane cleavage by site-2 protease Brown, MS, Davé, UP, Ye, J, Grishin, NV, Goldstein, JL	Proc Natl Acad Sci U S A	2000