S2P hydrolyzes SREBP1A,1C,2

Stable Identifier
Reaction [transition]
Homo sapiens
S2P hydrolyzes SREBF1A,1C,2
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S2P(MBTPS2), a membrane-bound protease in the Golgi, cleaves within the transmembrane region of SREBP1A/1C/2 (SREBF1A/1C/2), releasing the N-terminal domain of SREBP1A/1C/2 into the cytosol.

Literature References
PubMed ID Title Journal Year
8674110 Sterol-regulated release of SREBP-2 from cell membranes requires two sequential cleavages, one within a transmembrane segment

Brown, MS, Rawson, RB, Hua, X, Duncan, EA, Sakai, J, Goldstein, JL

Cell 1996
8156598 SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis

Brown, MS, Wang, X, Goldstein, JL, Hua, X, Sato, R

Cell 1994
9659902 Complementation cloning of S2P, a gene encoding a putative metalloprotease required for intramembrane cleavage of SREBPs

Brown, MS, Hasan, MT, Rawson, RB, Zelenski, NG, Ye, J, Nijhawan, D, Chang, TY, Sakai, J, Goldstein, JL

Mol Cell 1997
10805775 Asparagine-proline sequence within membrane-spanning segment of SREBP triggers intramembrane cleavage by site-2 protease

Brown, MS, Davé, UP, Ye, J, Grishin, NV, Goldstein, JL

Proc Natl Acad Sci U S A 2000
Catalyst Activity

metalloendopeptidase activity of MBTPS2 [Golgi membrane]

Orthologous Events
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