PhosphoChREBP (Thr 666) is exported to cytosol

Stable Identifier
R-HSA-164423
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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ChREBP (Carbohydrate Response Element Binding Protein) doubly phosphorylated at threonine 666 and serine 196 is inactive and is localized to the cytosol. Removal of the phosphate residue at serine 196 allows ChREBP to translocate between the cytosol and the nucleoplasm (Sakiyama et al. 2008).

Literature References
PubMed ID Title Journal Year
18606808 Regulation of nuclear import/export of carbohydrate response element-binding protein (ChREBP): interaction of an alpha-helix of ChREBP with the 14-3-3 proteins and regulation by phosphorylation

Sakiyama, H, Wynn, RM, Lee, WR, Fukasawa, M, Mizuguchi, H, Gardner, KH, Repa, JJ, Uyeda, K

J. Biol. Chem. 2008
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