PhosphoChREBP (Thr 653) is exported to cytosol

Stable Identifier
R-HSA-164423
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, nucleoplasm
ReviewStatus
5/5
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PhosphoChREBP (Thr 653) is exported to cytosol
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ChREBP (Carbohydrate Response Element Binding Protein) doubly phosphorylated at threonine 653 and serine 196 is inactive and is localized to the cytosol. Removal of the phosphate residue at serine 196 allows ChREBP to translocate between the cytosol and the nucleoplasm (Sakiyama et al. 2008).
Literature References
PubMed ID Title Journal Year
18606808 Regulation of nuclear import/export of carbohydrate response element-binding protein (ChREBP): interaction of an alpha-helix of ChREBP with the 14-3-3 proteins and regulation by phosphorylation

Lee, WR, Uyeda, K, Fukasawa, M, Repa, JJ, Gardner, KH, Mizuguchi, H, Wynn, RM, Sakiyama, H

J. Biol. Chem. 2008
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Event Information
Reverse Reaction
Nuclear transport of pChREBP (Thr 666) protein (Homo sapiens)
Orthologous Events
PhosphoChREBP (Thr 653) is exported to cytosol (Caenorhabditis elegans)
PhosphoChREBP (Thr 653) is exported to cytosol (Canis familiaris)
PhosphoChREBP (Thr 653) is exported to cytosol (Drosophila melanogaster)
PhosphoChREBP (Thr 653) is exported to cytosol (Rattus norvegicus)
PhosphoChREBP (Thr 653) is exported to cytosol (Sus scrofa)
Authored
Gopinathrao, G  (2005-05-19)
Created
Gopinathrao, G  (2005-05-19)
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