Nuclear transport of pChREBP (Thr 666) protein

Stable Identifier
R-HSA-163670
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Nuclear transport of pChREBP (Thr 666) protein
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
ChREBP (Carbohydrate Response Element Binding Protein) doubly phosphorylated at threonine 653 and serine 196 is inactive and is localized to the cytosol. Removal of the phosphate residue at serine 196 allows ChREBP to translocate between the cytosol and the nucleoplasm (Sakiyama et al. 2008).
Literature References
PubMed ID Title Journal Year
18606808 Regulation of nuclear import/export of carbohydrate response element-binding protein (ChREBP): interaction of an alpha-helix of ChREBP with the 14-3-3 proteins and regulation by phosphorylation

Sakiyama, H, Wynn, RM, Lee, WR, Fukasawa, M, Mizuguchi, H, Gardner, KH, Repa, JJ, Uyeda, K

J. Biol. Chem. 2008
Participants
Input
Output
Participates
as an event of
Event Information
Go Biological Process
import into nucleus (0051170)
Orthologous Events
Nuclear transport of pChREBP (Thr 666) protein (Caenorhabditis elegans)
Nuclear transport of pChREBP (Thr 666) protein (Canis familiaris)
Nuclear transport of pChREBP (Thr 666) protein (Danio rerio)
Nuclear transport of pChREBP (Thr 666) protein (Drosophila melanogaster)
Nuclear transport of pChREBP (Thr 666) protein (Rattus norvegicus)
Nuclear transport of pChREBP (Thr 666) protein (Sus scrofa)
Created
Gopinathrao, G  (2005-05-05)
Cite Us!