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DPM3 [endoplasmic reticulum membrane]
Stable Identifier
R-HSA-162825
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane
Synonyms
dolichyl-phosphate mannosyltransferase polypeptide 3
Icon
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of metabolism (Homo sapiens)
Diseases of glycosylation (Homo sapiens)
Diseases associated with glycosylation precursor biosynthesis (Homo sapiens)
Defective DPM1 causes DPM1-CDG (Homo sapiens)
Defective DPM1 does not transfer mannose to DOLP to form DOLPman (Homo sapiens)
DPM1 mutants:DPM2:DPM3 [endoplasmic reticulum membrane] (Homo sapiens)
DPM3 [endoplasmic reticulum membrane] (Homo sapiens)
Defective DPM2 causes DPM2-CDG (Homo sapiens)
Defective DPM2 does not transfer mannose to DOLP to form DOLPman (Homo sapiens)
DPM1:DPM2 Y23C:DPM3 [endoplasmic reticulum membrane] (Homo sapiens)
DPM3 [endoplasmic reticulum membrane] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Asparagine N-linked glycosylation (Homo sapiens)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Homo sapiens)
Synthesis of substrates in N-glycan biosythesis (Homo sapiens)
Synthesis of dolichyl-phosphate mannose (Homo sapiens)
dolichyl phosphate + GDP-alpha-D-mannose -> dolichyl phosphate D-mannose (Homo sapiens)
DPM1:DPM2:DPM3 [endoplasmic reticulum membrane] (Homo sapiens)
DPM3 [endoplasmic reticulum membrane] (Homo sapiens)
Post-translational modification: synthesis of GPI-anchored proteins (Homo sapiens)
Synthesis of dolichyl-phosphate mannose (Homo sapiens)
dolichyl phosphate + GDP-alpha-D-mannose -> dolichyl phosphate D-mannose (Homo sapiens)
DPM1:DPM2:DPM3 [endoplasmic reticulum membrane] (Homo sapiens)
DPM3 [endoplasmic reticulum membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9P2X0 DPM3
Gene Names
DPM3
Chain
chain:1-92
Reference Genes
BioGPS Gene:54344 DPM3
COSMIC (genes):DPM3 DPM3
CTD Gene:54344 DPM3
dbSNP Gene:54344 DPM3
ENSEMBL:ENSG00000179085.8 DPM3
HGNC:3007 DPM3
KEGG Gene (Homo sapiens):54344 DPM3
Monarch:54344 DPM3
NCBI Gene:54344 DPM3
OMIM:605951 DPM3
UCSC:Q9P2X0 DPM3
Reference Transcript
RefSeq:NM_018973.3 DPM3
RefSeq:NM_153741.1 DPM3
RefSeq:XM_017001498.1 DPM3
Other Identifiers
0000070471
11722238_a_at
16693952
219373_PM_at
219373_at
2437087
2437088
2437089
2437090
2437091
2437092
2437093
54344
65125_at
7920633
ADDON002617.hg
ADDON002657.hg
A_23_P250506
A_23_P72840
A_24_P179925
A_33_P3257460
GE62227
GO:0005515
GO:0005622
GO:0005737
GO:0005783
GO:0005789
GO:0005975
GO:0006486
GO:0006506
GO:0006629
GO:0008047
GO:0016020
GO:0016021
GO:0018406
GO:0019348
GO:0030176
GO:0031501
GO:0031647
GO:0032991
GO:0033185
GO:0035268
GO:0035269
GO:0036211
GO:0043226
GO:0050790
GO:0098772
GO:1901135
HMNXSV003035175
ILMN_1673323
ILMN_2376408
ILMN_2402674
PH_hs_0006086
TC01003303.hg
g9506552_3p_at
Participates
as a component of
DPM1:DPM2 Y23C:DPM3 [endoplasmic reticulum membrane] (Homo sapiens)
DPM1 mutants:DPM2:DPM3 [endoplasmic reticulum membrane] (Homo sapiens)
DPM1:DPM2:DPM3 [endoplasmic reticulum membrane] (Homo sapiens)
Other forms of this molecule
DPM3 L85S [endoplasmic reticulum membrane]
Inferred To
dpm3 [endoplasmic reticulum membrane]
(Xenopus tropicalis)
Dpm3 [endoplasmic reticulum membrane]
(Mus musculus)
Dpm3 [endoplasmic reticulum membrane]
(Rattus norvegicus)
DPM3 [endoplasmic reticulum membrane]
(Bos taurus)
DPM3 [endoplasmic reticulum membrane]
(Danio rerio)
Cross References
RefSeq
NP_714963.1
,
XP_016856987.1
,
NP_061846.2
OpenTargets
ENSG00000179085
GeneCards
Q9P2X0
HPA
ENSG00000179085-DPM3
Ensembl
ENSG00000179085
,
ENST00000341298
,
ENSP00000357384
,
ENSP00000344338
,
ENST00000368399
,
ENST00000368400
,
ENSP00000357385
PRO
Q9P2X0
Pharos - Targets
Q9P2X0
Orphanet
20271
HMDB Protein
HMDBP11714
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