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DPM3 [endoplasmic reticulum membrane]
Stable Identifier
R-HSA-162825
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane
Synonyms
dolichyl-phosphate mannosyltransferase polypeptide 3
Icon
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of metabolism (Homo sapiens)
Diseases of glycosylation (Homo sapiens)
Diseases associated with glycosylation precursor biosynthesis (Homo sapiens)
Defective DPM1 causes DPM1-CDG (Homo sapiens)
Defective DPM1 does not transfer mannose to DOLP to form DOLPman (Homo sapiens)
DPM1 mutants:DPM2:DPM3 [endoplasmic reticulum membrane] (Homo sapiens)
DPM3 [endoplasmic reticulum membrane] (Homo sapiens)
Defective DPM2 causes DPM2-CDG (Homo sapiens)
Defective DPM2 does not transfer mannose to DOLP to form DOLPman (Homo sapiens)
DPM1:DPM2 Y23C:DPM3 [endoplasmic reticulum membrane] (Homo sapiens)
DPM3 [endoplasmic reticulum membrane] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Asparagine N-linked glycosylation (Homo sapiens)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Homo sapiens)
Synthesis of substrates in N-glycan biosythesis (Homo sapiens)
Synthesis of dolichyl-phosphate mannose (Homo sapiens)
dolichyl phosphate + GDP-alpha-D-mannose -> dolichyl phosphate D-mannose (Homo sapiens)
DPM1:DPM2:DPM3 [endoplasmic reticulum membrane] (Homo sapiens)
DPM3 [endoplasmic reticulum membrane] (Homo sapiens)
Post-translational modification: synthesis of GPI-anchored proteins (Homo sapiens)
Synthesis of dolichyl-phosphate mannose (Homo sapiens)
dolichyl phosphate + GDP-alpha-D-mannose -> dolichyl phosphate D-mannose (Homo sapiens)
DPM1:DPM2:DPM3 [endoplasmic reticulum membrane] (Homo sapiens)
DPM3 [endoplasmic reticulum membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9P2X0 DPM3
Gene Names
DPM3
Chain
chain:1-92
Reference Genes
BioGPS Gene:54344 DPM3
COSMIC (genes):DPM3 DPM3
CTD Gene:54344 DPM3
dbSNP Gene:54344 DPM3
ENSEMBL:ENSG00000179085 DPM3
HGNC:3007 DPM3
KEGG:hsa:54344 DPM3
Monarch:54344 DPM3
NCBI Gene:54344 DPM3
OMIM:605951 DPM3
UCSC:Q9P2X0 DPM3
Reference Transcript
RefSeq:NM_018973.3 DPM3
RefSeq:XM_017001498.1 DPM3
RefSeq:NM_153741.1 DPM3
Participates
as a component of
DPM1:DPM2 Y23C:DPM3 [endoplasmic reticulum membrane] (Homo sapiens)
DPM1 mutants:DPM2:DPM3 [endoplasmic reticulum membrane] (Homo sapiens)
DPM1:DPM2:DPM3 [endoplasmic reticulum membrane] (Homo sapiens)
Other forms of this molecule
DPM3 L85S [endoplasmic reticulum membrane]
Inferred To
dpm3 [endoplasmic reticulum membrane]
(Danio rerio)
dpm3 [endoplasmic reticulum membrane]
(Xenopus tropicalis)
Dpm3 [endoplasmic reticulum membrane]
(Mus musculus)
Dpm3 [endoplasmic reticulum membrane]
(Rattus norvegicus)
DPM3 [endoplasmic reticulum membrane]
(Bos taurus)
DPM3 [endoplasmic reticulum membrane]
(Sus scrofa)
Cross References
ENSEMBL
ENST00000368399
,
ENST00000368400
,
ENST00000341298
,
ENSG00000179085
,
ENSP00000344338
,
ENSP00000357385
,
ENSP00000357384
OpenTargets
ENSG00000179085
GeneCards
DPM3
HPA
ENSG00000179085-DPM3
PRO
Q9P2X0
Pharos - Targets
Q9P2X0
GlyGen
Q9P2X0
Orphanet
DPM3
HMDB Protein
HMDBP11714
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