Tetramerization of procollagen VI

Stable Identifier
Reaction [binding]
Homo sapiens
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Collagen VI dimers combine to form tetramers before secretion (Furthmayr et al. 1983, von der Mark et al. 1984, Engel et al. 1985, Engvall et al. 1986, Colombatti et al. 1987). Collagen type VI chains are extensively post translationally modifed by the hydroxylation of proline and lysine residues (Myllyharju & Kivirikko 2004) and subsequent glycosylation of hydroxylysine, thought to be essential for tetramer formation and secretion (Sipila et al. 2007).

Literature References
PubMed ID Title Journal Year
3938630 Structure and macromolecular organization of type VI collagen

Engel, J, Furthmayr, H, Odermatt, E, von der Mark, H, Aumailley, M, Fleischmajer, R, Timpl, R

Ann N Y Acad Sci 1985
6307276 Electron-microscopical approach to a structural model of intima collagen

Furthmayr, H, Wiedemann, H, Timpl, R, Odermatt, E, Engel, J

Biochem J 1983
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