Reactome | Tetramerization of procollagen VI

Tetramerization of procollagen VI

Stable Identifier

R-HSA-1614461

Type

Reaction [binding]

Species

Homo sapiens

Compartment

endoplasmic reticulum lumen

ReviewStatus

5/5

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Collagen VI dimers combine to form tetramers before secretion (Furthmayr et al. 1983, von der Mark et al. 1984, Engel et al. 1985, Engvall et al. 1986, Colombatti et al. 1987). Collagen type VI chains are extensively post translationally modifed by the hydroxylation of proline and lysine residues (Myllyharju & Kivirikko 2004) and subsequent glycosylation of hydroxylysine, thought to be essential for tetramer formation and secretion (Sipila et al. 2007).

Literature References

PubMed ID	Title	Journal	Year
6307276	Electron-microscopical approach to a structural model of intima collagen Furthmayr, H, Wiedemann, H, Timpl, R, Odermatt, E, Engel, J	Biochem J	1983
3938630	Structure and macromolecular organization of type VI collagen Engel, J, Furthmayr, H, Odermatt, E, von der Mark, H, Aumailley, M, Fleischmajer, R, Timpl, R	Ann N Y Acad Sci	1985