Neu5Ac is cleaved from GM3 by NEU3 to form globoside (plasma membrane)

Stable Identifier
R-HSA-1605768
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Sialidase-3 (NEU3) cleaves Neu5Ac from GM3 in the plasma membrane. NEU3 is thought to play a role in modulating the ganglioside content of the lipid bilayer (Monti et al. 2000).

Literature References
PubMed ID Title Journal Year
10861246 Identification and expression of NEU3, a novel human sialidase associated to the plasma membrane

Monti, E, Bassi, MT, Papini, N, Riboni, M, Manzoni, M, Venerando, B, Croci, G, Preti, A, Ballabio, A, Tettamanti, G, Borsani, G

Biochem J 2000
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
exo-alpha-sialidase activity of NEU3 [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
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