NEU3 cleaves GM3 to form LacCer (plasma membrane)

Stable Identifier
R-HSA-1605768
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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NEU3 cleaves GM3 to form LacCer (plasma membrane)
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Sialidase-3 (NEU3) cleaves Neu5Ac from GM3 in the plasma membrane. NEU3 is thought to play a role in modulating the ganglioside content of the lipid bilayer (Monti et al. 2000).
Literature References
PubMed ID Title Journal Year
10861246 Identification and expression of NEU3, a novel human sialidase associated to the plasma membrane

Borsani, G, Preti, A, Manzoni, M, Papini, N, Venerando, B, Tettamanti, G, Bassi, MT, Ballabio, A, Croci, G, Riboni, M, Monti, E

Biochem J 2000
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Catalyst Activity

exo-alpha-sialidase activity of NEU3 [plasma membrane]

Physical Entity
NEU3 [plasma membrane] (Homo sapiens)
Activity
exo-alpha-sialidase activity (GO:0004308)
Orthologous Events
NEU3 cleaves GM3 to form LacCer (plasma membrane) (Bos taurus)
NEU3 cleaves GM3 to form LacCer (plasma membrane) (Canis familiaris)
NEU3 cleaves GM3 to form LacCer (plasma membrane) (Danio rerio)
NEU3 cleaves GM3 to form LacCer (plasma membrane) (Gallus gallus)
NEU3 cleaves GM3 to form LacCer (plasma membrane) (Mus musculus)
NEU3 cleaves GM3 to form LacCer (plasma membrane) (Rattus norvegicus)
NEU3 cleaves GM3 to form LacCer (plasma membrane) (Sus scrofa)
NEU3 cleaves GM3 to form LacCer (plasma membrane) (Xenopus tropicalis)
Authored
Jassal, B  (2011-09-21)
Reviewed
Stephan, R  (2011-10-31)
Created
Jassal, B  (2011-09-21)
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