PC is hydrolyzed to 1-acyl LPC by PLB1

Stable Identifier
R-HSA-1602399
Type
Reaction [transition]
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
ReviewStatus
5/5
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PC is hydrolyzed to 1-acyl LPC by PLB1
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
At the plasma membrane, phosphatidylcholine (PC) is hydrolyzed, removing one of its acyl groups, to 1-acyl lysophosphatidylcholine (LPC) by membrane-associated phospholipase B1 (PLB1) (Maury et al. 2002, Gassama-Diagne et al. 1992).
Literature References
PubMed ID Title Journal Year
12150957 Human epidermis is a novel site of phospholipase B expression

Maury, E, Prévost, MC, Nauze, M, Redoulès, D, Tarroux, R, Charvéron, M, Salles, JP, Perret, B, Chap, H, Gassama-Diagne, A

Biochem Biophys Res Commun 2002
1618844 Substrate specificity of phospholipase B from guinea pig intestine. A glycerol ester lipase with broad specificity

Gassama-Diagne, A, Rogalle, P, Fauvel, J, Willson, M, Klaébé, A, Chap, H

J Biol Chem 1992
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Output
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as an event of
Catalyst Activity

A2-type glycerophospholipase activity of PLB1 [plasma membrane]

Physical Entity
PLB1 [plasma membrane] (Homo sapiens)
Activity
A2-type glycerophospholipase activity (GO:0004623)
Orthologous Events
PC is hydrolyzed to 1-acyl LPC by PLB1 (Bos taurus)
PC is hydrolyzed to 1-acyl LPC by PLB1 (Caenorhabditis elegans)
PC is hydrolyzed to 1-acyl LPC by PLB1 (Canis familiaris)
PC is hydrolyzed to 1-acyl LPC by PLB1 (Drosophila melanogaster)
PC is hydrolyzed to 1-acyl LPC by PLB1 (Gallus gallus)
PC is hydrolyzed to 1-acyl LPC by PLB1 (Mus musculus)
PC is hydrolyzed to 1-acyl LPC by PLB1 (Rattus norvegicus)
PC is hydrolyzed to 1-acyl LPC by PLB1 (Sus scrofa)
Authored
Williams, MG  (2011-09-14)
Created
Williams, MG  (2011-09-14)
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