Activation of proMMP7 by MMP3

Stable Identifier
R-HSA-1592362
Type
Reaction [transition]
Species
Homo sapiens
Compartment
extracellular region
ReviewStatus
5/5
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Activation of proMMP7 by MMP3
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MMP3 activates MMP7 by cleavage of Glu94-Tyr95 (Imai et al. 1997).
Literature References
PubMed ID Title Journal Year
7896811 Matrix metalloproteinase 7 (matrilysin) from human rectal carcinoma cells. Activation of the precursor, interaction with other matrix metalloproteinases and enzymic properties

Imai, K, Yokohama, Y, Nakanishi, I, Ohuchi, E, Fujii, Y, Nakai, N, Okada, Y

J Biol Chem 1995
Participants
Input
Output
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as an event of
Catalyst Activity

serine-type endopeptidase activity of MMP3, CTSK, CTSL2 [extracellular region]

Physical Entity
MMP3, CTSK, CTSL2 [extracellular region] (Homo sapiens)
Activity
serine-type endopeptidase activity (GO:0004252)
Orthologous Events
Activation of proMMP7 by MMP3 (Bos taurus)
Activation of proMMP7 by MMP3 (Caenorhabditis elegans)
Activation of proMMP7 by MMP3 (Canis familiaris)
Activation of proMMP7 by MMP3 (Drosophila melanogaster)
Activation of proMMP7 by MMP3 (Gallus gallus)
Activation of proMMP7 by MMP3 (Mus musculus)
Activation of proMMP7 by MMP3 (Rattus norvegicus)
Activation of proMMP7 by MMP3 (Sus scrofa)
Activation of proMMP7 by MMP3 (Xenopus tropicalis)
Authored
Jupe, S  (2011-09-09)
Reviewed
Butler, GS  (2012-02-28)
Overall, CM  (2012-02-28)
Created
Jupe, S  (2011-09-09)
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