urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 1 (PAI-1) -> PAI-1:urokinase plasminogen activator (two-chain):uPAR

Stable Identifier
R-HSA-159005
Type
Reaction [transition]
Species
Homo sapiens
Compartment
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Activated (two-chain) urokinase plasminogen activator binds plasminogen activator inhibitor 1, a serpin, to form a stable, inactive complex that remains associated with uPAR on the plasma membrane (Cubellis et al. 1989).

Literature References
PubMed ID Title Journal Year
2544876 Accessibility of receptor-bound urokinase to type-1 plasminogen activator inhibitor

Cubellis, MV, Andreasen, P, Ragno, P, Mayer, M, Dano, K, Blasi, F

Proc Natl Acad Sci U S A 1989
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
serine-type endopeptidase inhibitor activity of SERPINE1-like proteins [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Created