urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 1 (PAI-1) -> PAI-1:urokinase plasminogen activator (two-chain):uPAR

Stable Identifier
R-HSA-159005
Type
Reaction [transition]
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
ReviewStatus
5/5
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urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 1 (PAI-1) -> PAI-1:urokinase plasminogen activator (two-chain):uPAR
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Activated (two-chain) urokinase plasminogen activator binds plasminogen activator inhibitor 1, a serpin, to form a stable, inactive complex that remains associated with uPAR on the plasma membrane (Cubellis et al. 1989).
Literature References
PubMed ID Title Journal Year
2544876 Accessibility of receptor-bound urokinase to type-1 plasminogen activator inhibitor

Blasi, F, Dano, K, Andreasen, P, Cubellis, MV, Mayer, M, Ragno, P

Proc Natl Acad Sci U S A 1989
Participants
Input
Output
Participates
as an event of
Catalyst Activity

serine-type endopeptidase inhibitor activity of SERPINE1-like proteins [plasma membrane]

Physical Entity
SERPINE1-like proteins [plasma membrane] (Homo sapiens)
Activity
serine-type endopeptidase inhibitor activity (GO:0004867)
Orthologous Events
urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 1 (PAI-1) -> PAI-1:urokinase plasminogen activator (two-chain):uPAR (Bos taurus)
urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 1 (PAI-1) -> PAI-1:urokinase plasminogen activator (two-chain):uPAR (Canis familiaris)
urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 1 (PAI-1) -> PAI-1:urokinase plasminogen activator (two-chain):uPAR (Mus musculus)
urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 1 (PAI-1) -> PAI-1:urokinase plasminogen activator (two-chain):uPAR (Rattus norvegicus)
urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 1 (PAI-1) -> PAI-1:urokinase plasminogen activator (two-chain):uPAR (Sus scrofa)
Authored
D'Eustachio, P  (2005-02-14)
Created
D'Eustachio, P  (2005-02-14)
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