Metabolism of nucleotides

Stable Identifier
Homo sapiens
Nucleotide metabolism
Locations in the PathwayBrowser
Click the image above or here to open this pathway in the Pathway Browser
Nucleotides and their derivatives are used for short-term energy storage (ATP, GTP), for intra- and extra-cellular signaling (cAMP; adenosine), as enzyme cofactors (NAD, FAD), and for the synthesis of DNA and RNA. Most dietary nucleotides are consumed by gut flora; the human body's own supply of these molecules is synthesized de novo. Additional metabolic pathways allow the interconversion of nucleotides, the salvage and reutilization of nucleotides released by degradation of DNA and RNA, the catabolism of excess nucleotides, and the transport of these molecules between the cytosol and the nucleus (Rudolph 1994). These pathways are regulated to control the total size of the intracellular nucleotide pool, to balance the relative amounts of individual nucleotides, and to couple the synthesis of deoxyribonucleotides to the onset of DNA replication (S phase of the cell cycle).

These pathways are also of major clinical interest as they are the means by which nucleotide analogues used as anti-viral and anti-tumor drugs are taken up by cells, activated, and catabolized (Weilin and Nordlund 2010). As well, differences in nucleotide metabolic pathways between humans and aplicomplexan parasites like Plasmodium have been exploited to design drugs to attack the latter (Hyde 2007).

The movement of nucleotides and purine and pyrimidine bases across lipid bilayer membranes, mediated by SLC transporters, is annotated as part of the module "transmembrane transport of small molecules".

Literature References
PubMed ID Title Journal Year
17266529 Targeting purine and pyrimidine metabolism in human apicomplexan parasites

Hyde, JE

Curr Drug Targets 2007
8283301 The biochemistry and physiology of nucleotides

Rudolph, FB

J Nutr 1994
20494131 Understanding specificity in metabolic pathways--structural biology of human nucleotide metabolism

Nordlund, P, Welin, M

Biochem Biophys Res Commun 2010
Event Information
Orthologous Events
Cite Us!