Reactome | factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst)

factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst)

Stable Identifier

R-HSA-158419

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

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factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst)

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Factor XI, bound to the cell surface, is converted to activated factor XI (factor XIa). In the body, this reaction occurs on the surfaces of activated platelets (Baglia et al. 2002). Small quantities of factor XI can be activated in a reaction catalyzed by factor XIIa, to initiate formation of a fibrin clot. However, the efficient activation of larger quantities of factor XI, needed to propagate the blood clotting process, appears to be mediated by thrombin (Baglia and Walsh 2000; Gailani and Broze 1993; Naito and Fujikawa 1991; Oliver et al. 1999; Monroe et al. 2002).

Literature References

PubMed ID	Title	Journal	Year
9888880	Thrombin activates factor XI on activated platelets in the absence of factor XII Oliver, JA, Monroe, DM, Roberts, HR, Hoffman, M	Arterioscler Thromb Vasc Biol	1999
2019570	Activation of human blood coagulation factor XI independent of factor XII. Factor XI is activated by thrombin and factor XIa in the presence of negatively charged surfaces. Naito, K, Fujikawa, K	J Biol Chem	1991
8338946	Factor XII-independent activation of factor XI in plasma: effects of sulfatides on tissue factor-induced coagulation Gailani, D, Broze, GJ Jr	Blood	1993
10781579	Thrombin-mediated feedback activation of factor XI on the activated platelet surface is preferred over contact activation by factor XIIa or factor XIa Baglia, FA, Walsh, PN	J Biol Chem	2000