Reactome | kallikrein + alpha2-macroglobulin -> kallikrein:alpha2-macrogloulin

kallikrein + alpha2-macroglobulin -> kallikrein:alpha2-macrogloulin

Stable Identifier

R-HSA-158340

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region

ReviewStatus

5/5

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kallikrein + alpha2-macroglobulin -> kallikrein:alpha2-macrogloulin

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Activated plasma kallikrein binds to alpha2-macroglobulin (Sottrup-Jensen L et al. 1984), forming a stable and enzymatically inactive complex. Under normal conditions in vivo, this reaction is estimated to account for approximately 16% of kallikrein inactivation, whereas C1 inhibitor (C1INH) is responsible for the majority of inhibition (Harpel PC et al. 1985). Earlier studies by Schapira M et al. suggest that C1INH accounts for 42% of plasma kallikrein inhibition, while α2-macroglobulin contributes about 48% (Schapira M et al., 1981).

Literature References

PubMed ID	Title	Journal	Year
2579948	Distribution of plasma kallikrein between C-1 inactivator and alpha 2-macroglobulin in plasma utilizing a new assay for alpha 2-macroglobulin-kallikrein complexes Harpel, PC, Lewin, MF, Kaplan, AP	J Biol Chem	1985
6203908	Primary structure of human alpha 2-macroglobulin. V. The complete structure. Sottrup-Jensen, L, Stepanik, TM, Kristensen, T, Wierzbicki, DM, Jones, CM, Lonblad, PB, Magnusson, S, Petersen, TE	J Biol Chem	1984