kallikrein + alpha2-macroglobulin -> kallikrein:alpha2-macrogloulin

Stable Identifier
R-HSA-158340
Type
Reaction [binding]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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Activated plasma kallikrein binds to alpha2-macroglobulin (Sottrup-Jensen L et al. 1984), forming a stable and enzymatically inactive complex. Under normal conditions in vivo, this reaction is estimated to account for approximately 16% of kallikrein inactivation, whereas C1 inhibitor (C1INH) is responsible for the majority of inhibition (Harpel PC et al. 1985). Earlier studies by Schapira M et al. suggest that C1INH accounts for 42% of plasma kallikrein inhibition, while α2-macroglobulin contributes about 48% (Schapira M et al., 1981).
Literature References
PubMed ID Title Journal Year
2579948 Distribution of plasma kallikrein between C-1 inactivator and alpha 2-macroglobulin in plasma utilizing a new assay for alpha 2-macroglobulin-kallikrein complexes

Harpel, PC, Lewin, MF, Kaplan, AP

J Biol Chem 1985
6203908 Primary structure of human alpha 2-macroglobulin. V. The complete structure.

Sottrup-Jensen, L, Stepanik, TM, Kristensen, T, Wierzbicki, DM, Jones, CM, Lonblad, PB, Magnusson, S, Petersen, TE

J Biol Chem 1984
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