kallikrein + alpha2-macroglobulin -> kallikrein:alpha2-macrogloulin

Stable Identifier
R-HSA-158340
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Activated kallikrein binds to alpha2-macroglobulin (Sottrup-Jensen et al. 1984), forming a stable and enzymatically inactive complex. Under normal conditions in vivo, this reaction appears to be responsible for the inactivation of about 1/6 of activated kallikrein (with C1Inh responsible for the inactivation of about 5/6) (Harpel et al. 1985).

Literature References
PubMed ID Title Journal Year
6203908 Primary structure of human alpha 2-macroglobulin. V. The complete structure.

Sottrup-Jensen, L, Stepanik, TM, Kristensen, T, Wierzbicki, DM, Jones, CM, Lonblad, PB, Magnusson, S, Petersen, TE

J Biol Chem 1984
2579948 Distribution of plasma kallikrein between C-1 inactivator and alpha 2-macroglobulin in plasma utilizing a new assay for alpha 2-macroglobulin-kallikrein complexes

Harpel, PC, Lewin, MF, Kaplan, AP

J Biol Chem 1985
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