Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA

Stable Identifier
R-HSA-156823
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Although the mechanism through which L13a prevents translation initiation has not been determined, Mazumder et al. (2003) have described four alternatives. L13a could (1) inhibit the function of eIF4F, (2) block the recruitment of the 43S preinitiation complex, (3) prevent scanning of the 43S complex to the initiation codon, or 4) interfere with joining of the 60S ribosomal subunit.

Literature References
PubMed ID Title Journal Year
12588972 Transcript-selective translational silencing by gamma interferon is directed by a novel structural element in the ceruloplasmin mRNA 3' untranslated region

Sampath, P, Mazumder, B, Seshadri, V, Fox, PL

Mol Cell Biol 2003
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