Collagen type VIII degradation by MMP1

Stable Identifier
Reaction [transition]
Homo sapiens
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Collagen type VIII is a short chain, network-forming collagen,thought to play a role in tissue remodeling and repair (Shuttleworth 1997, Weitkamp et al. 1999). There are two alpha chain subtypes, found in a ratio of two alpha-1 to one alpha-2 chains (Mann et al. 1990) in the typical collagen heterotrimer. Studies suggest that type VIII collagen is a major component of the hexagonal lattice seen in Descemet's membrane (Mann et al. 1990). Mutations in both alpha chains have been associated with Fuchs endothelial corneal dystrophy (FECD), a degenerative disease of the corneal endothelium (Jun et al. 2012).

Collagen type VIII can be degraded by MMP1 (Sage et al. 1983, 1984).

Literature References
PubMed ID Title Journal Year
6694361 Type VIII collagen. Synthesis by normal and malignant cells in culture

Balian, G, Sage, H, Vogel, AM, Bornstein, P

Lab Invest 1984
Catalyst Activity

metalloendopeptidase activity of MMP1(100-469) [extracellular region]

Orthologous Events
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