Reactome | Collagen type V degradation by MMP2,9,10

Collagen type V degradation by MMP2,9,10

Stable Identifier

R-HSA-1564164

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region

ReviewStatus

5/5

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Collagen type V degradation by MMP2,9,10

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Type V collagen is a fibril-forming collagen forming a group with collagen types I, II, III and XI (Gelse et al. 2003). Three different alpha chains exist that can combine in three distinct trimers. Collagen V forms fibrils that are associated with type I and to a lesser extent III collagen, as a minor but critical component of bone matrix, corneal stroma and the interstitial matrix of muscle, liver, lung and placenta (Birk et al. 1988). COL5A1-/- mice have an almost complete lack of collagen fibrils reflecting a central role in fibrillogenesis (Wenstrup et al. 2004). Type V collagen mutation results in a range of connective tissue diseases including Ehlers-Danlos syndrome (EDS), which is a heterogeneous group of disorders characterized by joint hypermobility and skin hyperextensibility, thinness and fragility. These result from mutations in the COL5A1 and COL5A2 genes (Michalickova et al. 1998, Schwarze et al. 2000). Type V collagen is digested by MMP2 (Murphy et al. 1981, Veidal et al. 2011), MMP10 (Nicholson et al. 1989), and MMP9 (Murphy et al. 1982, Watanabe et al. 1993, Pourmotabbed et al. 1994, Niyibizi et al. 1994, Veidal et al. 2011).

Literature References

PubMed ID	Title	Journal	Year
2548603	Human and rat malignant-tumor-associated mRNAs encode stromelysin-like metalloproteinases Nicholson, R, Murphy, G, Breathnach, R	Biochemistry	1989
22382088	MMP mediated type V collagen degradation (C5M) is elevated in ankylosing spondylitis Veidal, SS, Larsen, DV, Chen, X, Sun, S, Zheng, Q, Bay-Jensen, AC, Leeming, DJ, Nawrocki, A, Larsen, MR, Schett, G, Karsdal, MA	Clin Biochem	2012