BH2 binding can lead to eNOS uncoupling

Stable Identifier
R-HSA-1497796
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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BH2 binding can lead to eNOS uncoupling
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The oxidation product of BH4, 7,8-dihydrobiopterin (BH2), can compete with BH4 for binding to eNOS. This can lead to the uncoupling of eNOS and can result in the formation of reactive oxygen species (Vasquez-Vivar et al. 2002).
Literature References
PubMed ID Title Journal Year
11879202 The ratio between tetrahydrobiopterin and oxidized tetrahydrobiopterin analogues controls superoxide release from endothelial nitric oxide synthase: an EPR spin trapping study

Vásquez-Vivar, J, Martasek, P, Whitsett, J, Joseph, J, Kalyanaraman, B

Biochem J 2002
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Catalyst Activity

tetrahydrobiopterin binding activity of p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane]

Physical Entity
p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] (Homo sapiens)
Activity
tetrahydrobiopterin binding (GO:0034617)
Orthologous Events
BH2 binding can lead to eNOS uncoupling (Bos taurus)
BH2 binding can lead to eNOS uncoupling (Caenorhabditis elegans)
BH2 binding can lead to eNOS uncoupling (Dictyostelium discoideum)
BH2 binding can lead to eNOS uncoupling (Drosophila melanogaster)
BH2 binding can lead to eNOS uncoupling (Mus musculus)
BH2 binding can lead to eNOS uncoupling (Rattus norvegicus)
BH2 binding can lead to eNOS uncoupling (Saccharomyces cerevisiae)
BH2 binding can lead to eNOS uncoupling (Schizosaccharomyces pombe)
Authored
Jassal, B  (2011-08-17)
Reviewed
D'Eustachio, P  (2011-08-23)
Hill, DP  (2024-08-02)
Created
Jassal, B  (2011-08-17)
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