GPCho is hydrolyzed to Cho and G3P by GPCPD1

Stable Identifier
R-HSA-1483116
Type
Reaction
Species
Homo sapiens
Compartment
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In the cytosol, glycerophosphocholine phosphodiesterase (GPCPD1, also known as GDE5) hydrolyzes glycerophosphocholine (GPCho) to produce choline (Cho) and glycerol-3-phosphate (G3P). This event has been inferred from mice. GPCPD1 has also been characterized in humans (Ota et al. 2004).

Literature References
PubMed ID Title Journal Year
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs

Shibahara, T, Shigeta, K, Goto, Y, Takiguchi, S, Kanehori, K, Tanai, H, Tanase, TO, Nagahari, K, Kusano, J, Nomura, N, Satoh, N, Takeuchi, K, Hishigaki, H, Sudo, H, Isono, Y, Yamada, K, Hotuta, T, Inagaki, H, Kobatake, N, Hata, H, Sasaki, N, Nomura, Y, Saito, K, Imose, N, Ichihara, T, Shiohata, N, Yoshikawa, Y, Ohmori, Y, Nakagawa, K, Ohara, O, Watanabe, K, Ninomiya, K, Matsunawa, H, Makita, H, Shirai, Y, Nagase, T, Okitani, R, Togashi, T, Senoh, A, Yamamoto, J, Oshima, A, Kamihara, K, Tanigami, A, Yuuki, H, Musashino, K, Hikiji, T, Kodaira, H, Sasaki, M, Momiyama, H, Iwayanagi, T, Ota, T, Mizushima-Sugano, J, Senba, T, Kawabata, A, Matsumura, K, Shiratori, A, Murakami, K, Sugiyama, A, Fujimori, Y, Ishida, S, Takemoto, M, Takahashi-Fujii, A, Murakawa, K, Shimizu, F, Nakai, K, Tanaka, T, Togiya, S, Irie, R, Wakebe, H, Oyama, M, Kimata, M, Nakajima, Y, Itakura, S, Tanikawa, M, Ikema, Y, Kikkawa, E, Arita, M, Fujiwara, T, Fukuzumi, Y, Ozaki, K, Suzuki, O, Komai, F, Morinaga, M, Komiyama, M, Hirao, M, Takami, S, Kaku, Y, Terashima, Y, Hara, R, Wagatsuma, M, Nishi, T, Furuya, T, Katsuta, N, Otsuki, T, Moriya, S, Tashiro, H, Kikuchi, H, Yosida, M, Aotsuka, S, Sekine, M, Kawakami, B, Kanda, K, Yamashita, R, Nishikawa, T, Nakagawa, S, Nagai, K, Sugano, S, Sano, S, Hayashi, K, Watanabe, T, Kawakami, T, Itoh, T, Noguchi, S, Takahashi, Y, Okamoto, S, Sato, H, Takahashi, M, Kawai, Y, Yada, T, Yamashita, H, Mizuno, T, Nakamura, Y, Wakamatsu, A, Chiba, Y, Okumura, K, Nakamura, Y, Sato, K, Hara, H, Yamazaki, M, Watanabe, M, Yamazaki, M, Satoh, T, Watanabe, M, Abe, K, Kumagai, A, Suzuki, Y, Masuho, Y, Isogai, T, Yokoi, T, Yasuda, T, Fujimori, K, Mizoguchi, H, Ishibashi, T, Watanabe, S, Ishii, S, Kimura, K, Ono, T, Komatsu, T, Sugiyama, T, Ono, Y, Kondo, H, Sugawara, M, Fujii, Y, Omura, Y, Obayashi, M, Hiraoka, S, Hosoiri, T

Nat Genet 2004
Participants
Participates
Catalyst Activity

glycerophosphodiester phosphodiesterase activity of GPCPD1 [cytosol]

Inferred From
Cross References
Rhea
Authored
Created
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