Cho is phosphorylated to PCho by CHK dimer

Stable Identifier
R-HSA-1483004
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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In the cytosol, choline kinase alpha subunit (CHKA) homodimer, choline kinase beta subunit (CHKB) dimer, or CHKA:CHKB heterodimer phosphorylates choline (Cho) to produce phosphocholine (PCho) (Malito et al. 2006, Gallego-Ortega et al. 2009).

Literature References
PubMed ID Title Journal Year
17007874 Elucidation of human choline kinase crystal structures in complex with the products ADP or phosphocholine

Malito, E, Sekulic, N, Too, WC, Konrad, M, Lavie, A

J Mol Biol 2006
19915674 Differential role of human choline kinase alpha and beta enzymes in lipid metabolism: implications in cancer onset and treatment

Gallego-Ortega, D, Ramirez de Molina, A, Ramos, MA, Valdes-Mora, F, Barderas, MG, Sarmentero-Estrada, J, Lacal, JC

PLoS One 2009
Participants
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
choline kinase activity of CHK dimer [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Created