Reactome | Cho is phosphorylated to PCho by CHK dimer

Cho is phosphorylated to PCho by CHK dimer

Stable Identifier

R-HSA-1483004

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Cho is phosphorylated to PCho by CHK dimer

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In the cytosol, choline kinase alpha subunit (CHKA) homodimer, choline kinase beta subunit (CHKB) dimer, or CHKA:CHKB heterodimer phosphorylates choline (Cho) to produce phosphocholine (PCho) (Malito et al. 2006, Gallego-Ortega et al. 2009).

Literature References

PubMed ID	Title	Journal	Year
19915674	Differential role of human choline kinase alpha and beta enzymes in lipid metabolism: implications in cancer onset and treatment Gallego-Ortega, D, Ramirez de Molina, A, Ramos, MA, Valdes-Mora, F, Barderas, MG, Sarmentero-Estrada, J, Lacal, JC	PLoS One	2009
17007874	Elucidation of human choline kinase crystal structures in complex with the products ADP or phosphocholine Malito, E, Sekulic, N, Too, WC, Konrad, M, Lavie, A	J Mol Biol	2006