Cho is phosphorylated to PCho by CHK dimer

Stable Identifier
R-HSA-1483004
Type
Reaction
Species
Homo sapiens
Compartment
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In the cytosol, choline kinase alpha subunit (CHKA) homodimer, choline kinase beta subunit (CHKB) dimer, or CHKA:CHKB heterodimer phosphorylates choline (Cho) to produce phosphocholine (PCho) (Malito et al. 2006, Gallego-Ortega et al. 2009).

Literature References
PubMed ID Title Journal Year
19915674 Differential role of human choline kinase alpha and beta enzymes in lipid metabolism: implications in cancer onset and treatment

Ramirez de Molina, A, Lacal, JC, Barderas, MG, Valdes-Mora, F, Ramos, MA, Sarmentero-Estrada, J, Gallego-Ortega, D

PLoS One 2009
17007874 Elucidation of human choline kinase crystal structures in complex with the products ADP or phosphocholine

Sekulic, N, Too, WC, Konrad, M, Malito, E, Lavie, A

J Mol Biol 2006
Participants
Participates
Catalyst Activity

choline kinase activity of CHK dimer [cytosol]

Orthologous Events
Authored
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