Reactome | DHAP is converted to 1-acyl GO3P by GNPAT

DHAP is converted to 1-acyl GO3P by GNPAT

Stable Identifier

R-HSA-1483002

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, peroxisomal membrane

ReviewStatus

5/5

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DHAP is converted to 1-acyl GO3P by GNPAT

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Dihydroxyacetone phosphate (DHAP) is converted to 1-acyl glycerone 3-phosphate (GO3P) by the enzyme dihydroxyacetone phosphate acyltransferase (GNPAT) (de Vet et al. 1999, Ofman et al. 1994). This reaction step links Glycerolipid metabolism to Ether lipid metabolism.

Literature References

PubMed ID	Title	Journal	Year
8186247	Purification of peroxisomal acyl-CoA: dihydroxyacetonephosphate acyltransferase from human placenta Wanders, RJA, Ofman, R	Biochim Biophys Acta	1994
10553003	Ether lipid biosynthesis: alkyl-dihydroxyacetonephosphate synthase protein deficiency leads to reduced dihydroxyacetonephosphate acyltransferase activities IJlst, L, Oostheim, W, van den Bosch, H, de Vet, EC, Dekker, C, Moser, HW	J Lipid Res	1999