DHAP is converted to 1-acyl GO3P by GNPAT

Stable Identifier
R-HSA-1483002
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, peroxisomal membrane
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DHAP is converted to 1-acyl GO3P by GNPAT
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Dihydroxyacetone phosphate (DHAP) is converted to 1-acyl glycerone 3-phosphate (GO3P) by the enzyme dihydroxyacetone phosphate acyltransferase (GNPAT) (de Vet et al. 1999, Ofman et al. 1994). This reaction step links Glycerolipid metabolism to Ether lipid metabolism.

Literature References
PubMed ID Title Journal Year
10553003 Ether lipid biosynthesis: alkyl-dihydroxyacetonephosphate synthase protein deficiency leads to reduced dihydroxyacetonephosphate acyltransferase activities

de Vet, EC, IJlst, L, Oostheim, W, Dekker, C, Moser, HW, van den Bosch, H

J Lipid Res 1999
8186247 Purification of peroxisomal acyl-CoA: dihydroxyacetonephosphate acyltransferase from human placenta

Ofman, R, Wanders, RJ

Biochim Biophys Acta 1994
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
glycerone-phosphate O-acyltransferase activity of GNPAT [peroxisomal membrane]
Physical Entity
GNPAT [peroxisomal membrane]
Activity
glycerone-phosphate O-acyltransferase activity (0016287)
Orthologous Events
DHAP is converted to 1-acyl GO3P by GNPAT (Caenorhabditis elegans)
DHAP is converted to 1-acyl GO3P by GNPAT (Canis familiaris)
DHAP is converted to 1-acyl GO3P by GNPAT (Danio rerio)
DHAP is converted to 1-acyl GO3P by GNPAT (Mus musculus)
DHAP is converted to 1-acyl GO3P by GNPAT (Rattus norvegicus)
DHAP is converted to 1-acyl GO3P by GNPAT (Sus scrofa)
DHAP is converted to 1-acyl GO3P by GNPAT (Xenopus tropicalis)
Authored
Williams, MG  (2011-09-14)
Created
Williams, MG  (2011-08-12)
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