Reactome | PG is hydrolyzed to 1-acyl LPG by PLA2[1]

PG is hydrolyzed to 1-acyl LPG by PLA2[1]

Stable Identifier

R-HSA-1482900

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane, cytosol

ReviewStatus

5/5

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PG is hydrolyzed to 1-acyl LPG by PLA2[1]

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At the endoplasmic reticulum (ER) membrane, phosphatidylglycerol (PG) is hydrolyzed, and has one of its acyl chains cleaved off, by cytosolic phospholipase A2 alpha/beta/delta/zeta (PLA2G4A/B/D/F) (Ghomashchi et al. 2010) to form 1-acyl lysophosphatidylglycerol (LPG).

Literature References

PubMed ID	Title	Journal	Year
20705608	Interfacial kinetic and binding properties of mammalian group IVB phospholipase A2 (cPLA2beta) and comparison with the other cPLA2 isoforms Ghomashchi, F, Naika, GS, Bollinger, JG, Aloulou, A, Lehr, M, Leslie, CC, Gelb, MH	J Biol Chem	2010