Reactome | PE is hydrolyzed to 1-acyl LPE by PLA2[2]

PE is hydrolyzed to 1-acyl LPE by PLA2[2]

Stable Identifier

R-HSA-1482884

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane, cytosol

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

PE is hydrolyzed to 1-acyl LPE by PLA2[2]

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

At the endoplasmic reticulum (ER) membrane, phosphatidylethanolamine (PE) is hydrolyzed, and has one of its acyl chains cleaved off, by phospholipase A2 to form 1-acyl lysophosphatidylethanolamine (LPE). The phospholipases are either cytosolic phospholipase A2 alpha/beta/delta/epsilon/zeta (PLA2G(4A/B/D/E/F) (Ghosh et al. 2006, Yamashita et al. 2009, Yamashita et al. 1999, Ghomashchi et al. 2010), 85 kDa calcium-independent phospholipase A2 (PLA2G6) (Larsson et al. 1998, Ma et al. 1999, Larsson Forsell et al. 1999), group XVI phospholipase A2 (PLA2G16) (Duncan et al. 2008), or Phospholipase B-like 1 (PLBD1) (Xu et al. 2009). PLBD1 acts as a phospholipase A2 but in addition has the propensity to hydrolyze the lysophospholipid formed in its initial reaction.

Literature References

PubMed ID	Title	Journal	Year
20705608	Interfacial kinetic and binding properties of mammalian group IVB phospholipase A2 (cPLA2beta) and comparison with the other cPLA2 isoforms Ghomashchi, F, Naika, GS, Bollinger, JG, Aloulou, A, Lehr, M, Leslie, CC, Gelb, MH	J Biol Chem	2010
10336645	The human calcium-independent phospholipase A2 gene multiple enzymes with distinct properties from a single gene Larsson Forsell, PK, Kennedy, BP, Claesson, HE	Eur J Biochem	1999
9417066	Multiple splice variants of the human calcium-independent phospholipase A2 and their effect on enzyme activity Larsson, PK, Claesson, HE, Kennedy, BP	J Biol Chem	1998
15944408	Roles of C-terminal processing, and involvement in transacylation reaction of human group IVC phospholipase A2 (cPLA2gamma) Yamashita, A, Kamata, R, Kawagishi, N, Nakanishi, H, Suzuki, H, Sugiura, T, Waku, K	J Biochem	2005
10092647	Human pancreatic islets express mRNA species encoding two distinct catalytically active isoforms of group VI phospholipase A2 (iPLA2) that arise from an exon-skipping mechanism of alternative splicing of the transcript from the iPLA2 gene on chromosome 22q13.1 Ma, Z, Wang, X, Nowatzke, W, Ramanadham, S, Turk, J	J Biol Chem	1999
16617059	Identification of the expressed form of human cytosolic phospholipase A2beta (cPLA2beta): cPLA2beta3 is a novel variant localized to mitochondria and early endosomes Ghosh, M, Loper, R, Gelb, MH, Leslie, CC	J Biol Chem	2006
19019078	The identification of a phospholipase B precursor in human neutrophils Xu, S, Zhao, L, Larsson, A, Venge, P	FEBS J	2009
19501189	Subcellular localization and lysophospholipase/transacylation activities of human group IVC phospholipase A2 (cPLA2gamma) Yamashita, A, Tanaka, K, Kamata, R, Kumazawa, T, Suzuki, N, Koga, H, Waku, K, Sugiura, T	Biochim Biophys Acta	2009
18614531	Identification and functional characterization of adipose-specific phospholipase A2 (AdPLA) Duncan, RE, Sarkadi-Nagy, E, Jaworski, K, Ahmadian, M, Sul, HS	J Biol Chem	2008