PE is hydrolyzed to 1-acyl LPE by PLA2[2]

Stable Identifier
R-HSA-1482884
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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At the endoplasmic reticulum (ER) membrane, phosphatidylethanolamine (PE) is hydrolyzed, and has one of its acyl chains cleaved off, by phospholipase A2 to form 1-acyl lysophosphatidylethanolamine (LPE). The phospholipases are either cytosolic phospholipase A2 alpha/beta/delta/epsilon/zeta (PLA2G(4A/B/D/E/F) (Ghosh et al. 2006, Yamashita et al. 2009, Yamashita et al. 1999, Ghomashchi et al. 2010), 85 kDa calcium-independent phospholipase A2 (PLA2G6) (Larsson et al. 1998, Ma et al. 1999, Larsson Forsell et al. 1999), group XVI phospholipase A2 (PLA2G16) (Duncan et al. 2008), or Phospholipase B-like 1 (PLBD1) (Xu et al. 2009). PLBD1 acts as a phospholipase A2 but in addition has the propensity to hydrolyze the lysophospholipid formed in its initial reaction.

Literature References
PubMed ID Title Journal Year
20705608 Interfacial kinetic and binding properties of mammalian group IVB phospholipase A2 (cPLA2beta) and comparison with the other cPLA2 isoforms

Ghomashchi, F, Naika, GS, Bollinger, JG, Aloulou, A, Lehr, M, Leslie, CC, Gelb, MH

J Biol Chem 2010
10336645 The human calcium-independent phospholipase A2 gene multiple enzymes with distinct properties from a single gene

Larsson Forsell, PK, Kennedy, BP, Claesson, HE

Eur J Biochem 1999
9417066 Multiple splice variants of the human calcium-independent phospholipase A2 and their effect on enzyme activity

Larsson, PK, Claesson, HE, Kennedy, BP

J Biol Chem 1998
15944408 Roles of C-terminal processing, and involvement in transacylation reaction of human group IVC phospholipase A2 (cPLA2gamma)

Yamashita, A, Kamata, R, Kawagishi, N, Nakanishi, H, Suzuki, H, Sugiura, T, Waku, K

J Biochem 2005
10092647 Human pancreatic islets express mRNA species encoding two distinct catalytically active isoforms of group VI phospholipase A2 (iPLA2) that arise from an exon-skipping mechanism of alternative splicing of the transcript from the iPLA2 gene on chromosome 22q13.1

Ma, Z, Wang, X, Nowatzke, W, Ramanadham, S, Turk, J

J Biol Chem 1999
16617059 Identification of the expressed form of human cytosolic phospholipase A2beta (cPLA2beta): cPLA2beta3 is a novel variant localized to mitochondria and early endosomes

Ghosh, M, Loper, R, Gelb, MH, Leslie, CC

J Biol Chem 2006
19019078 The identification of a phospholipase B precursor in human neutrophils

Xu, S, Zhao, L, Larsson, A, Venge, P

FEBS J 2009
19501189 Subcellular localization and lysophospholipase/transacylation activities of human group IVC phospholipase A2 (cPLA2gamma)

Yamashita, A, Tanaka, K, Kamata, R, Kumazawa, T, Suzuki, N, Koga, H, Waku, K, Sugiura, T

Biochim Biophys Acta 2009
18614531 Identification and functional characterization of adipose-specific phospholipase A2 (AdPLA)

Duncan, RE, Sarkadi-Nagy, E, Jaworski, K, Ahmadian, M, Sul, HS

J Biol Chem 2008
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
phospholipase A2 activity of PLA2(2) [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Created