PI is hydrolyzed to 1-acyl LPI by PLA2[12]

Stable Identifier
R-HSA-1482868
Type
Reaction [transition]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane, cytosol
ReviewStatus
5/5
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PI is hydrolyzed to 1-acyl LPI by PLA2[12]
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At the endoplasmic reticulum (ER) membrane, phosphatidylinositol (PI) is hydrolyzed, and has one of its acyl chains cleaved off, by membrane-associated phospholipase A2 gamma 2A (PLA2G2A) (Singer et al. 2002) or by cytosolic phospholipase A2 gamma (PLA2G4C) (Ghomashchi et al. 2010), to form 1-acyl lysophosphatidylinositol (LPI).
Literature References
PubMed ID Title Journal Year
20705608 Interfacial kinetic and binding properties of mammalian group IVB phospholipase A2 (cPLA2beta) and comparison with the other cPLA2 isoforms

Ghomashchi, F, Naika, GS, Bollinger, JG, Aloulou, A, Lehr, M, Leslie, CC, Gelb, MH

J Biol Chem 2010
12359733 Interfacial kinetic and binding properties of the complete set of human and mouse groups I, II, V, X, and XII secreted phospholipases A2

Singer, AG, Ghomashchi, F, Le Calvez, C, Bollinger, J, Bezzine, S, Rouault, M, Sadilek, M, Nguyen, E, Lazdunski, M, Lambeau, G, Gelb, MH

J Biol Chem 2002
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Catalyst Activity

A2-type glycerophospholipase activity of PLA2(12) [endoplasmic reticulum membrane]

Physical Entity
PLA2(12) [endoplasmic reticulum membrane] (Homo sapiens)
Activity
A2-type glycerophospholipase activity (GO:0004623)
Orthologous Events
PI is hydrolyzed to 1-acyl LPI by PLA2[12] (Bos taurus)
PI is hydrolyzed to 1-acyl LPI by PLA2[12] (Caenorhabditis elegans)
PI is hydrolyzed to 1-acyl LPI by PLA2[12] (Danio rerio)
PI is hydrolyzed to 1-acyl LPI by PLA2[12] (Dictyostelium discoideum)
PI is hydrolyzed to 1-acyl LPI by PLA2[12] (Gallus gallus)
PI is hydrolyzed to 1-acyl LPI by PLA2[12] (Mus musculus)
PI is hydrolyzed to 1-acyl LPI by PLA2[12] (Rattus norvegicus)
PI is hydrolyzed to 1-acyl LPI by PLA2[12] (Saccharomyces cerevisiae)
PI is hydrolyzed to 1-acyl LPI by PLA2[12] (Schizosaccharomyces pombe)
PI is hydrolyzed to 1-acyl LPI by PLA2[12] (Sus scrofa)
Authored
Williams, MG  (2011-09-14)
Created
Williams, MG  (2011-08-12)
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