Reactome | PI is hydrolyzed to 1-acyl LPI by PLA2[12]

PI is hydrolyzed to 1-acyl LPI by PLA2[12]

Stable Identifier

R-HSA-1482868

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane, cytosol

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PI is hydrolyzed to 1-acyl LPI by PLA2[12]

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At the endoplasmic reticulum (ER) membrane, phosphatidylinositol (PI) is hydrolyzed, and has one of its acyl chains cleaved off, by membrane-associated phospholipase A2 gamma 2A (PLA2G2A) (Singer et al. 2002) or by cytosolic phospholipase A2 gamma (PLA2G4C) (Ghomashchi et al. 2010), to form 1-acyl lysophosphatidylinositol (LPI).

Literature References

PubMed ID	Title	Journal	Year
12359733	Interfacial kinetic and binding properties of the complete set of human and mouse groups I, II, V, X, and XII secreted phospholipases A2 Singer, AG, Ghomashchi, F, Le Calvez, C, Bollinger, J, Bezzine, S, Rouault, M, Sadilek, M, Nguyen, E, Lazdunski, M, Lambeau, G, Gelb, MH	J Biol Chem	2002
20705608	Interfacial kinetic and binding properties of mammalian group IVB phospholipase A2 (cPLA2beta) and comparison with the other cPLA2 isoforms Ghomashchi, F, Naika, GS, Bollinger, JG, Aloulou, A, Lehr, M, Leslie, CC, Gelb, MH	J Biol Chem	2010