PI is hydrolyzed to 1-acyl LPI by PLA2[11]

Stable Identifier
R-HSA-1482825
Type
Reaction
Species
Homo sapiens
Compartment
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At the endoplasmic reticulum (ER) membrane, phosphatidylinositol (PI) is hydrolyzed, and has one of its acyl chains cleaved off, by a phospholipase A2 to form 1-acyl lysophosphatidylinositol (LPI). The phospholipases are either cytosolic phospholipase A2 alpha/beta/zeta (PLA2G4A/D/F) (Ghomashchi et al. 2010), group XVI phospholipase A2 (PLA2G16) (Duncan et al. 2008), or Phospholipase B-like 1 (PLBD1) (Xu et al. 2009). PLBD1 also acts as a phospholipase A2 but in addition has the propensity to hydrolyze the lysophospholipid formed in its initial reaction.

Literature References
PubMed ID Title Journal Year
20705608 Interfacial kinetic and binding properties of mammalian group IVB phospholipase A2 (cPLA2beta) and comparison with the other cPLA2 isoforms

Lehr, M, Gelb, MH, Aloulou, A, Naika, GS, Bollinger, JG, Ghomashchi, F, Leslie, CC

J Biol Chem 2010
19019078 The identification of a phospholipase B precursor in human neutrophils

Venge, P, Zhao, L, Larsson, A, Xu, S

FEBS J 2009
18614531 Identification and functional characterization of adipose-specific phospholipase A2 (AdPLA)

Duncan, RE, Ahmadian, M, Jaworski, K, Sarkadi-Nagy, E, Sul, HS

J Biol Chem 2008
Participants
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Catalyst Activity

phospholipase A2 activity of PLA2(11) [cytosol]

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