PI is hydrolyzed to 1-acyl LPI by PLA2[11]

Stable Identifier
R-HSA-1482825
Type
Reaction [transition]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane, cytosol
ReviewStatus
5/5
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PI is hydrolyzed to 1-acyl LPI by PLA2[11]
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At the endoplasmic reticulum (ER) membrane, phosphatidylinositol (PI) is hydrolyzed, and has one of its acyl chains cleaved off, by a phospholipase A2 to form 1-acyl lysophosphatidylinositol (LPI). The phospholipases are either cytosolic phospholipase A2 alpha/beta/zeta (PLA2G4A/D/F) (Ghomashchi et al. 2010), group XVI phospholipase A2 (PLA2G16) (Duncan et al. 2008), or Phospholipase B-like 1 (PLBD1) (Xu et al. 2009). PLBD1 also acts as a phospholipase A2 but in addition has the propensity to hydrolyze the lysophospholipid formed in its initial reaction.
Literature References
PubMed ID Title Journal Year
20705608 Interfacial kinetic and binding properties of mammalian group IVB phospholipase A2 (cPLA2beta) and comparison with the other cPLA2 isoforms

Ghomashchi, F, Naika, GS, Bollinger, JG, Aloulou, A, Lehr, M, Leslie, CC, Gelb, MH

J Biol Chem 2010
19019078 The identification of a phospholipase B precursor in human neutrophils

Xu, S, Zhao, L, Larsson, A, Venge, P

FEBS J 2009
18614531 Identification and functional characterization of adipose-specific phospholipase A2 (AdPLA)

Duncan, RE, Sarkadi-Nagy, E, Jaworski, K, Ahmadian, M, Sul, HS

J Biol Chem 2008
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Catalyst Activity

A2-type glycerophospholipase activity of PLA2(11) [cytosol]

Physical Entity
PLA2(11) [cytosol] (Homo sapiens)
Activity
A2-type glycerophospholipase activity (GO:0004623)
Orthologous Events
PI is hydrolyzed to 1-acyl LPI by PLA2[11] (Bos taurus)
PI is hydrolyzed to 1-acyl LPI by PLA2[11] (Canis familiaris)
PI is hydrolyzed to 1-acyl LPI by PLA2[11] (Danio rerio)
PI is hydrolyzed to 1-acyl LPI by PLA2[11] (Dictyostelium discoideum)
PI is hydrolyzed to 1-acyl LPI by PLA2[11] (Gallus gallus)
PI is hydrolyzed to 1-acyl LPI by PLA2[11] (Mus musculus)
PI is hydrolyzed to 1-acyl LPI by PLA2[11] (Rattus norvegicus)
PI is hydrolyzed to 1-acyl LPI by PLA2[11] (Saccharomyces cerevisiae)
PI is hydrolyzed to 1-acyl LPI by PLA2[11] (Schizosaccharomyces pombe)
PI is hydrolyzed to 1-acyl LPI by PLA2[11] (Sus scrofa)
PI is hydrolyzed to 1-acyl LPI by PLA2[11] (Xenopus tropicalis)
Authored
Williams, MG  (2011-09-14)
Created
Williams, MG  (2011-08-12)
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