Reactome | PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM)

PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM)

Stable Identifier

R-HSA-1482604

Type

Reaction [transition]

Species

Homo sapiens

Compartment

mitochondrial outer membrane, cytosol

ReviewStatus

5/5

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PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM)

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At the outer mitochondrial (OM) membrane, phosphatidic acid (PA) is hydrolyzed, and has one of its acyl chains cleaved off, by phospholipase A2 alpha/beta/delta/zeta (PLA2G4A/B/D/F) to form 1-acyl lysophosphatidic acid (LPA) (Ghomashchi et al. 2010).

Literature References

PubMed ID	Title	Journal	Year
20705608	Interfacial kinetic and binding properties of mammalian group IVB phospholipase A2 (cPLA2beta) and comparison with the other cPLA2 isoforms Lehr, M, Gelb, MH, Aloulou, A, Naika, GS, Bollinger, JG, Ghomashchi, F, Leslie, CC	J Biol Chem	2010