1-acyl LPA is acylated to PA by AGPAT5 (OM)

Stable Identifier
R-HSA-1482548
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial outer membrane, cytosol
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
1-acyl LPA is acylated to PA by AGPAT5 (OM)
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

At the outer mitochondrial (OM) membrane, 1-acyl lysophosphatidic acid (LPA) is acylated to phosphatidic acid (PA) by the enzyme 1-acyl-sn-glycerol-3-phosphate acyltransferases epsilon (AGPAT5) (Prasad et al. 2011).

Literature References
PubMed ID Title Journal Year
21173190 Enzymatic activities of the human AGPAT isoform 3 and isoform 5: localization of AGPAT5 to mitochondria

Prasad, SS, Garg, A, Agarwal, AK

J Lipid Res 2011
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
1-acylglycerol-3-phosphate O-acyltransferase activity of AGPAT5 [mitochondrial outer membrane]
Physical Entity
AGPAT5 [mitochondrial outer membrane]
Activity
1-acylglycerol-3-phosphate O-acyltransferase activity (0003841)
Orthologous Events
1-acyl LPA is acylated to PA by AGPAT5 (OM) (Bos taurus)
1-acyl LPA is acylated to PA by AGPAT5 (OM) (Caenorhabditis elegans)
1-acyl LPA is acylated to PA by AGPAT5 (OM) (Canis familiaris)
1-acyl LPA is acylated to PA by AGPAT5 (OM) (Danio rerio)
1-acyl LPA is acylated to PA by AGPAT5 (OM) (Dictyostelium discoideum)
1-acyl LPA is acylated to PA by AGPAT5 (OM) (Gallus gallus)
1-acyl LPA is acylated to PA by AGPAT5 (OM) (Mus musculus)
1-acyl LPA is acylated to PA by AGPAT5 (OM) (Rattus norvegicus)
1-acyl LPA is acylated to PA by AGPAT5 (OM) (Saccharomyces cerevisiae)
1-acyl LPA is acylated to PA by AGPAT5 (OM) (Schizosaccharomyces pombe)
1-acyl LPA is acylated to PA by AGPAT5 (OM) (Sus scrofa)
1-acyl LPA is acylated to PA by AGPAT5 (OM) (Xenopus tropicalis)
Authored
Williams, MG  (2011-09-14)
Created
Williams, MG  (2011-08-12)