Reactome | 1-acyl LPC is acylated to PC by LPCAT

1-acyl LPC is acylated to PC by LPCAT

Stable Identifier

R-HSA-1482547

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane, cytosol

ReviewStatus

5/5

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At the endoplasmic reticulum (ER) membrane, lysophospholipid acyltransferases acylate 1-acyl lysophosphatidylcholine (LPC) to form phosphatidylcholine (PC). The lysophospholipid acyltransferases involved are: lysophosphatidylcholine acyltransferase 1 (LPCAT1) (Nakanishi et al. 2006, Chen et al. 2006); lysophosphatidylcholine acyltransferase 2 (LPCAT2) (Shindou et al. 2006); lysophospholipid acyltransferase 5 (LPCAT3) (Hishikawa et al. 2008, Zhao et al. 2008, Gijon et al. 2008, Jain et al. 2009, Kazachkov et al. 2008); lysophospholipid acyltransferase LPCAT4 (LPCAT4) aka LPEAT2 (Cao et al. 2008, Ye et al. 2005); or lysophospholipid acyltransferase 2 (MBOAT2) aka LPCAT4 (Hishikawa et al. 2008, Gijon et al. 2008).

Literature References

PubMed ID	Title	Journal	Year
18772128	Lysophospholipid acyltransferases and arachidonate recycling in human neutrophils Gijon, MA, Riekhof, WR, Zarini, S, Murphy, RC, Voelker, DR	J Biol Chem	2008
16243729	Cloning and characterization a novel human 1-acyl-sn-glycerol-3-phosphate acyltransferase gene AGPAT7 Ye, GM, Chen, C, Huang, S, Han, DD, Guo, JH, Wan, B, Yu, L	DNA Seq	2005
18195019	Identification and characterization of a major liver lysophosphatidylcholine acyltransferase Zhao, Y, Chen, YQ, Bonacci, TM, Bredt, DS, Li, S, Bensch, WR, Moller, DE, Kowala, M, Konrad, RJ, Cao, G	J Biol Chem	2008
16704971	Cloning and characterization of mouse lung-type acyl-CoA:lysophosphatidylcholine acyltransferase 1 (LPCAT1). Expression in alveolar type II cells and possible involvement in surfactant production Nakanishi, H, Shindou, H, Hishikawa, D, Harayama, T, Ogasawara, R, Suwabe, A, Taguchi, R, Shimizu, T	J Biol Chem	2006
18458083	Molecular identification of a novel mammalian brain isoform of acyl-CoA:lysophospholipid acyltransferase with prominent ethanolamine lysophospholipid acylating activity, LPEAT2 Cao, J, Shan, D, Revett, T, Li, D, Wu, L, Liu, W, Tobin, JF, Gimeno, RE	J Biol Chem	2008
16864775	Identification and characterization of a lysophosphatidylcholine acyltransferase in alveolar type II cells Chen, X, Hyatt, BA, Mucenski, ML, Mason, RJ, Shannon, JM	Proc Natl Acad Sci U S A	2006
17182612	A single enzyme catalyzes both platelet-activating factor production and membrane biogenesis of inflammatory cells. Cloning and characterization of acetyl-CoA:LYSO-PAF acetyltransferase Shindou, H, Hishikawa, D, Nakanishi, H, Harayama, T, Ishii, S, Taguchi, R, Shimizu, T	J Biol Chem	2007