2-acyl LPG is acylated to PG by CRLS1 (IM)

Stable Identifier
R-HSA-1482546
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial inner membrane, mitochondrial matrix
ReviewStatus
5/5
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2-acyl LPG is acylated to PG by CRLS1 (IM)
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At the inner mitochondrial membrane (IM), cardiolipin synthase (CRLS1) acylates 2-acyl lysophosphatidylglycerol (LPG) to form phosphatidylglycerol (PG) (Nie et al. 2010).
Literature References
PubMed ID Title Journal Year
20025994 A novel function of the human CLS1 in phosphatidylglycerol synthesis and remodeling

Nie, J, Hao, X, Chen, D, Han, X, Chang, Z, Shi, Y

Biochim Biophys Acta 2010
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Catalyst Activity

2-acylglycerol-3-phosphate O-acyltransferase activity of CRLS1 [mitochondrial inner membrane]

Physical Entity
CRLS1 [mitochondrial inner membrane] (Homo sapiens)
Activity
2-acylglycerol-3-phosphate O-acyltransferase activity (GO:0047144)
Orthologous Events
2-acyl LPG is acylated to PG by CRLS1 (IM) (Bos taurus)
2-acyl LPG is acylated to PG by CRLS1 (IM) (Caenorhabditis elegans)
2-acyl LPG is acylated to PG by CRLS1 (IM) (Danio rerio)
2-acyl LPG is acylated to PG by CRLS1 (IM) (Drosophila melanogaster)
2-acyl LPG is acylated to PG by CRLS1 (IM) (Gallus gallus)
2-acyl LPG is acylated to PG by CRLS1 (IM) (Mus musculus)
2-acyl LPG is acylated to PG by CRLS1 (IM) (Rattus norvegicus)
2-acyl LPG is acylated to PG by CRLS1 (IM) (Saccharomyces cerevisiae)
2-acyl LPG is acylated to PG by CRLS1 (IM) (Schizosaccharomyces pombe)
2-acyl LPG is acylated to PG by CRLS1 (IM) (Sus scrofa)
Authored
Williams, MG  (2011-09-14)
Created
Williams, MG  (2011-08-12)
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