Reactome | 1-acyl LPG is acylated to PG by LPGAT

1-acyl LPG is acylated to PG by LPGAT

Stable Identifier

R-HSA-1482539

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane, cytosol

ReviewStatus

5/5

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At the endoplasmic reticulum (ER) membrane, lysophospholipid acyltransferases acylate 1-acyl lysophosphatidylglycerol (LPG) to form phosphatidylglycerol (PG). The lysophospholipid acyltransferases involved are: lysophosphatidylcholine acyltransferase 1 (LPCAT1) (Nakanishi et al. 2006, Chen et al. 2006), lysophospholipid acyltransferase LPCAT4 (LPCAT4) aka LPEAT2 (Cao et al. 2008, Ye et al. 2005); or acyl-CoA:lysophosphatidylglycerol acyltransferase (LPGAT1) (Yang et al. 2004).

Literature References

PubMed ID	Title	Journal	Year
15485873	Identification and characterization of a gene encoding human LPGAT1, an endoplasmic reticulum-associated lysophosphatidylglycerol acyltransferase Yang, Y, Cao, J, Shi, Y	J Biol Chem	2004
16243729	Cloning and characterization a novel human 1-acyl-sn-glycerol-3-phosphate acyltransferase gene AGPAT7 Ye, GM, Chen, C, Huang, S, Han, DD, Guo, JH, Wan, B, Yu, L	DNA Seq	2005
16704971	Cloning and characterization of mouse lung-type acyl-CoA:lysophosphatidylcholine acyltransferase 1 (LPCAT1). Expression in alveolar type II cells and possible involvement in surfactant production Nakanishi, H, Shindou, H, Hishikawa, D, Harayama, T, Ogasawara, R, Suwabe, A, Taguchi, R, Shimizu, T	J Biol Chem	2006
18458083	Molecular identification of a novel mammalian brain isoform of acyl-CoA:lysophospholipid acyltransferase with prominent ethanolamine lysophospholipid acylating activity, LPEAT2 Cao, J, Shan, D, Revett, T, Li, D, Wu, L, Liu, W, Tobin, JF, Gimeno, RE	J Biol Chem	2008
16864775	Identification and characterization of a lysophosphatidylcholine acyltransferase in alveolar type II cells Chen, X, Hyatt, BA, Mucenski, ML, Mason, RJ, Shannon, JM	Proc Natl Acad Sci U S A	2006