Reactome | 1-acyl LPG is acylated to PG by LPGAT

1-acyl LPG is acylated to PG by LPGAT

Stable Identifier

R-HSA-1482539

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane, cytosol

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

At the endoplasmic reticulum (ER) membrane, lysophospholipid acyltransferases acylate 1-acyl lysophosphatidylglycerol (LPG) to form phosphatidylglycerol (PG). The lysophospholipid acyltransferases involved are: lysophosphatidylcholine acyltransferase 1 (LPCAT1) (Nakanishi et al. 2006, Chen et al. 2006), lysophospholipid acyltransferase LPCAT4 (LPCAT4) aka LPEAT2 (Cao et al. 2008, Ye et al. 2005); or acyl-CoA:lysophosphatidylglycerol acyltransferase (LPGAT1) (Yang et al. 2004).

Literature References

PubMed ID	Title	Journal	Year
15485873	Identification and characterization of a gene encoding human LPGAT1, an endoplasmic reticulum-associated lysophosphatidylglycerol acyltransferase Shi, Y, Yang, Y, Cao, J	J Biol Chem	2004
16243729	Cloning and characterization a novel human 1-acyl-sn-glycerol-3-phosphate acyltransferase gene AGPAT7 Chen, C, Wan, B, Huang, S, Ye, GM, Guo, JH, Han, DD, Yu, L	DNA Seq	2005
16704971	Cloning and characterization of mouse lung-type acyl-CoA:lysophosphatidylcholine acyltransferase 1 (LPCAT1). Expression in alveolar type II cells and possible involvement in surfactant production Shindou, H, Suwabe, A, Ogasawara, R, Nakanishi, H, Taguchi, R, Shimizu, T, Harayama, T, Hishikawa, D	J Biol Chem	2006
18458083	Molecular identification of a novel mammalian brain isoform of acyl-CoA:lysophospholipid acyltransferase with prominent ethanolamine lysophospholipid acylating activity, LPEAT2 Revett, T, Tobin, JF, Cao, J, Li, D, Shan, D, Gimeno, RE, Wu, L, Liu, W	J Biol Chem	2008
16864775	Identification and characterization of a lysophosphatidylcholine acyltransferase in alveolar type II cells Chen, X, Mucenski, ML, Mason, RJ, Hyatt, BA, Shannon, JM	Proc Natl Acad Sci U S A	2006